Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010

Structure

electron microscopy · 1 distinct chain.

Ligands and binding sites

• 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 16 copies · chains D, C, A, B
• LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains D, A, B, C
• JT0 · 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide · ligand · 4 copies · chains D, A, B, C
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains D, A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6PQO · Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist… · the same entry in another collection · chain B against B, TM-score 1.00
• O75762 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain D against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O75762
• Elsewhere: RCSB PDB 6PQO · PDBe 6PQO · UniProt O75762