Research workbench
Muscarinic acetylcholine receptor 1-G11 protein complex
Analyse Muscarinic acetylcholine receptor 1-G11 protein complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OIJ
- Type
- protein
- Length
- 1,152 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I) subunit alpha-1, guanine nucleotide-binding…
- UniProt
- A0A3B3ITX3, P29992, P11229, P62873, P59768
- Ligands
- Y01, IXO
- Pockets
- 11 · best druggability 0.83
Structure
electron microscopy · 5 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1, guanine nucleotide-binding protein subunit alpha-11 | protein | 225 | 43% helix, 16% strand | A0A3B3ITX3, P29992 |
| R | Muscarinic acetylcholine receptor M1 | protein | 293 | 79% helix, 0% strand | P11229 |
| H | Antibody fragment | protein | 236 | 1% helix, 43% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 339 | 9% helix, 44% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 59 | 47% helix, 0% strand | P59768 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 2 copies · chains R
- IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.83 | 0.86 | 78 | empty |
| 2 | 107 | 0.80 | 0.98 | 23 | IXO |
| 3 | 592 | 0.73 | 0.81 | 55 | empty |
| 4 | 406 | 0.67 | 0.80 | 61 | empty |
| 5 | 216 | 0.55 | 0.78 | 26 | empty |
Interfaces
6 interfaces between chains.
- B–G · 2095 Ų buried · 16 hydrogen bonds · protein-protein
- A–R · 1443 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1262 Ų buried · 15 hydrogen bonds · protein-protein
- A–H · 613 Ų buried · 7 hydrogen bonds · protein-protein
- H–B · 444 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6OIJ · Muscarinic acetylcholine receptor 1-G11 protein complex · the same entry in another collection · chain G against G, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P11229 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M1 (P11229) · a predicted model of the same protein · chain R against A, TM-score 0.94
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.91
- P29992 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein subunit alpha-11… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3B3ITX3
- Every structure of UniProt P29992
- Every structure of UniProt P11229
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 6OIJ · PDBe 6OIJ · UniProt A0A3B3ITX3 · UniProt P29992 · UniProt P11229 · UniProt P62873 · UniProt P59768
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