UniProt P11229
Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1 (P11229)
Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1 (UniProt P11229), EC 3.2.1.17: 11 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 26 pockets. Binding sites…
- UniProt
- P11229
- Protein
- Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine…
- EC
- 3.2.1.17
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 26 · 5 records with a druggable one
Structures
12 records of P11229 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CXV | Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium | x-ray diffraction | A | 0HK, Y01 | 4 (best 0.76) |
| 5CXV | Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist tiotropium | x-ray diffraction | A | — | — |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | R | IXO, Y01 | 5 (best 0.83) |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | R | IXO, Y01 | — |
| 6WJC | Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex | x-ray diffraction | A | ACM, Y01, OIN | 6 (best 0.85) |
| 6WJC | Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex | x-ray diffraction | A | ACM, Y01, OIN | — |
| 6ZFZ | Structure of M1-star-T4L in complex with 77-lh-28-1 at 2.17A | x-ray diffraction | A | QJT, OLA, PO4 | — |
| 6ZG4 | Structure of M1-StaR-T4L in complex with HTL0009936 at 2.35A | x-ray diffraction | A | QK8, OLA, PO4 | 4 (best 0.77) |
| 6ZG4 | Structure of M1-star-T4L in complex with HTL0009936 at 2.35A | x-ray diffraction | A | QK8, OLA, PO4 | — |
| 6ZG9 | Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A | x-ray diffraction | A | QK2, OLA, PO4 | 7 (best 0.79) |
| 6ZG9 | Structure of M1-star-T4L in complex with GSK1034702 at 2.5A | x-ray diffraction | A | QK2, OLA, PO4 | — |
| P11229 | AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M1 (P11229) | predicted | A | — | — |
Ligands
- OLA · Oleic acid · in 5 records
- PO4 · Phosphate ion · in 5 records
- Y01 · Cholesterol hemisuccinate · in 5 records
- ACM · Acetamide · in 2 records
- IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · in 2 records
- OIN · (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2R)-3-hydroxy-2-phenylpropanoate · in 2 records
- QK2 · 7-fluoranyl-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1~{H}-benzimidazol-2-one · in 2 records
- QK8 · Ethyl (4~{S})-4-[4-[(1-methylcyclobutyl) carbamoyl]piperidin-1-yl]azepane-1-carboxylate · in 2 records
- 0HK · (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane · in 1 record
- QJT · 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one · in 1 record
Experiment against prediction
- 6OIJ chain R against the predicted model P11229: TM-score 0.94, RMSD 1.79 Å
- 6OIJ chain R against the predicted model P11229: TM-score 0.94, RMSD 1.79 Å
- 5CXV chain A against the predicted model P11229: TM-score 0.67, RMSD 2.69 Å
- 5CXV chain A against the predicted model P11229: TM-score 0.67, RMSD 2.69 Å
- 6ZFZ chain A against the predicted model P11229: TM-score 0.65, RMSD 3.15 Å
- 6ZG4 chain A against the predicted model P11229: TM-score 0.65, RMSD 3.07 Å
- 6ZG4 chain A against the predicted model P11229: TM-score 0.65, RMSD 3.07 Å
- 6WJC chain A against the predicted model P11229: TM-score 0.65, RMSD 3.34 Å
- 6WJC chain A against the predicted model P11229: TM-score 0.65, RMSD 3.34 Å
- 6ZG9 chain A against the predicted model P11229: TM-score 0.65, RMSD 3.13 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.