Research workbench
Crystal structure of the CA2+/CAM complex with independent peptides of KV7.4 (KCNQ4) a & B domains
Analyse Crystal structure of the CA2+/CAM complex with independent peptides of KV7.4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N5W
- Type
- protein
- Length
- 188 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily kqt member 4; Calmodulin-1
- UniProt
- P56696, P0DP23
- Ligands
- CA
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium voltage-gated channel subfamily kqt member 4 | protein | 19 | 79% helix, 0% strand | P56696 |
| B | Potassium voltage-gated channel subfamily kqt member 4 | protein | 25 | 88% helix, 0% strand | P56696 |
| C | Calmodulin-1 | protein | 144 | 58% helix, 7% strand | P0DP23 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.59 | 0.80 | 23 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1173 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 950 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 450 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6N5W · Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A &… · the same entry in another collection · chain A against A, TM-score 1.00
- P56696 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain B against A, TM-score 0.84
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain C against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56696
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 6N5W · PDBe 6N5W · UniProt P56696 · UniProt P0DP23
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