UniProt P56696
Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4 (P56696)
Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4 (UniProt P56696): 19 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 33 pockets. Binding sites, druggability and…
- UniProt
- P56696
- Protein
- Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 33 · 2 records with a druggable one
Structures
20 records of P56696 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OVC | Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels | x-ray diffraction | A | — | — |
| 2OVC | Crystal structure of a coiled-coil tetramerization domain from KV7.4 channels | x-ray diffraction | A | — | — |
| 4GOW | Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex | x-ray diffraction | A | — | — |
| 4GOW | Crystal structure of CA2+/CAM:KV7.4 (KCNQ4) B helix complex | x-ray diffraction | A | — | — |
| 6B8L | Crystal structure of the APO/CAM:KV7.4 (KCNQ4) ab domain complex | x-ray diffraction | A, C, E, G | SO4 | — |
| 6B8M | Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak | x-ray diffraction | A, C, E, G | SO4 | — |
| 6B8M | Crystal structure of the CA2+/CAM:KV7.4 (KCNQ4) ab domain complex, 1 mm CACL2 soak | x-ray diffraction | A, C, E, G | SO4 | — |
| 6B8N | Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak | x-ray diffraction | A, C, E, G | SO4 | 13 (best 0.75) |
| 6B8N | Crystal structure of the CA2+/CAM:KV7.4 (KCNQ4) ab domain complex, 10 um CACL2 soak | x-ray diffraction | A, C, E, G | SO4 | — |
| 6B8P | Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex | x-ray diffraction | A, C, E, G | SO4 | — |
| 6B8P | Crystal structure of the MG2+/CAM:KV7.4 (KCNQ4) ab domain complex | x-ray diffraction | A, C, E, G | SO4 | — |
| 6N5W | Crystal structure of the CA2+/CAM complex with independent peptides of KV7.4 (KCNQ4) a & B domains | x-ray diffraction | A, B | — | — |
| 7BYL | Cryo-EM structure of human KCNQ4 | electron microscopy | A, C, E, G | PT5, K | — |
| 7BYM | Cryo-EM structure of human KCNQ4 with retigabine | electron microscopy | A, C, E, G | PT5, FBX, K | — |
| 7BYN | Cryo-EM structure of human KCNQ4 with linopirdine | electron microscopy | A, C, E, G | PT5, K, FCC | 20 (best 0.86) |
| 7BYN | Cryo-EM structure of human KCNQ4 with linopirdine | electron microscopy | A, C, E, G | PT5, K, FCC | — |
| 7VNP | Structure of human KCNQ4-ML213 complex with PIP2 | electron microscopy | A, C, E, G | PT5, K, 7YV | — |
| 7VNQ | Structure of human KCNQ4-ML213 complex in nanodisc | electron microscopy | A, C, E, G | 7YV, K | — |
| 7VNR | Structure of human KCNQ4-ML213 complex in digitonin | electron microscopy | A, C, E, G | 7YV, K | — |
| P56696 | AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt member 4… | predicted | A | — | — |
Ligands
- K · Potassium ion · in 7 records
- SO4 · Sulfate ion · in 7 records
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 5 records
- 7YV · (1S,2S,4R)-N-(2,4,6-trimethylphenyl) bicyclo[2.2.1]heptane-2-carboxamid · in 3 records
- FCC · 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one · in 2 records
- FBX · Ethyl N-[2-azanyl-4-[(4-fluorophenyl) methylamino]phenyl]carbamate · in 1 record
Experiment against prediction
- 6N5W chain B against the predicted model P56696: TM-score 0.84, RMSD 0.47 Å
- 2OVC chain A against the predicted model P56696: TM-score 0.81, RMSD 0.69 Å
- 2OVC chain A against the predicted model P56696: TM-score 0.81, RMSD 0.69 Å
- 7VNP chain A against the predicted model P56696: TM-score 0.78, RMSD 3.88 Å
- 7VNQ chain A against the predicted model P56696: TM-score 0.78, RMSD 3.84 Å
- 7VNR chain A against the predicted model P56696: TM-score 0.76, RMSD 4.13 Å
- 4GOW chain A against the predicted model P56696: TM-score 0.75, RMSD 1.12 Å
- 4GOW chain A against the predicted model P56696: TM-score 0.75, RMSD 1.12 Å
- 6N5W chain A against the predicted model P56696: TM-score 0.72, RMSD 0.51 Å
- 7BYM chain A against the predicted model P56696: TM-score 0.71, RMSD 4.69 Å
Elsewhere
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