Cryo-EM structure of human KCNQ4 with retigabine

Structure

electron microscopy · 2 distinct chains.

Ligands and binding sites

• PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · ligand · 4 copies · chains A, C, E, G
• FBX · Ethyl N-[2-azanyl-4-[(4-fluorophenyl) methylamino]phenyl]carbamate · ligand · 4 copies · chains A, E, G, C
• K · Potassium ion · metal · 3 copies · chains A, C, E, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7BYM · Cryo-EM structure of human KCNQ4 with retigabine · the same entry in another collection · chain G against G, TM-score 1.00
• P56696 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.71
• P0DP25 · AlphaFold monomer V2.0 prediction for calmodulin-3 (P0DP25) · a predicted model of the same protein · chain D against A, TM-score 0.55

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P42212
• Every structure of UniProt P56696
• Every structure of UniProt P0DP25
• Elsewhere: RCSB PDB 7BYM · PDBe 7BYM · UniProt P42212 · UniProt P56696 · UniProt P0DP25