UniProt P0DP25
Calmodulin-3 (P0DP25)
Calmodulin-3 (UniProt P0DP25): 22 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 114 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0DP25
- Protein
- Calmodulin-3
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 114 · 14 records with a druggable one
Structures
23 records of P0DP25 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7BYL | Cryo-EM structure of human KCNQ4 | electron microscopy | B, D, F, H | — | 4 (best 0.56) |
| 7BYL | Cryo-EM structure of human KCNQ4 | electron microscopy | B, D, F, H | — | — |
| 7BYM | Cryo-EM structure of human KCNQ4 with retigabine | electron microscopy | B, D, F, H | — | 7 (best 0.56) |
| 7BYM | Cryo-EM structure of human KCNQ4 with retigabine | electron microscopy | B, D, F, H | — | — |
| 7BYN | Cryo-EM structure of human KCNQ4 with linopirdine | electron microscopy | B, D, F, H | — | 7 (best 0.70) |
| 7BYN | Cryo-EM structure of human KCNQ4 with linopirdine | electron microscopy | B, D, F, H | — | — |
| 7CR3 | human KCNQ2-CaM in apo state | electron microscopy | F, C, E, H | — | 11 (best 0.79) |
| 7CR3 | Human KCNQ2-cam in apo state | electron microscopy | F, C, E, H | — | 11 (best 0.79) |
| 7CR4 | human KCNQ2-CaM in complex with ztz240 | electron microscopy | H, C, E, G | — | 9 (best 0.80) |
| 7CR4 | Human KCNQ2-cam in complex with ZTZ240 | electron microscopy | H, C, E, G | — | — |
| 7CR7 | human KCNQ2-CaM in complex with retigabine | electron microscopy | F, C, E, H | — | 6 (best 0.76) |
| 7CR7 | Human KCNQ2-cam in complex with retigabine | electron microscopy | F, C, E, H | — | — |
| 7VNP | Structure of human KCNQ4-ML213 complex with PIP2 | electron microscopy | B, D, F, H | — | 12 (best 0.76) |
| 7VNP | Structure of human KCNQ4-ML213 complex with PIP2 | electron microscopy | B, D, F, H | — | — |
| 7VNQ | Structure of human KCNQ4-ML213 complex in nanodisc | electron microscopy | B, D, F, H | — | 6 (best 0.76) |
| 7VNQ | Structure of human KCNQ4-ML213 complex in nanodisc | electron microscopy | B, D, F, H | — | — |
| 7VNR | Structure of human KCNQ4-ML213 complex in digitonin | electron microscopy | B, D, F, H | — | 7 (best 0.69) |
| 7VNR | Structure of human KCNQ4-ML213 complex in digitonin | electron microscopy | B, D, F, H | — | — |
| 7XNI | human KCNQ1-CaM in apo state | electron microscopy | C, E, F, H | — | 6 (best 0.79) |
| 7XNK | human KCNQ1-CaM in complex with ML277 | electron microscopy | B, D, F, H | — | 8 (best 0.69) |
| 7XNL | human KCNQ1-CaM-ML277-PIP2 complex in state A | electron microscopy | B, D, F, H | PIO | 8 (best 0.70) |
| 7XNN | human KCNQ1-CaM-ML277-PIP2 complex in state B | electron microscopy | A, D, F, H | — | 12 (best 0.75) |
| P0DP25 | AlphaFold monomer V2.0 prediction for calmodulin-3 (P0DP25) | predicted | A | — | — |
Ligands
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 1 record
Experiment against prediction
- 7CR3 chain E against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain F against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain H against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain E against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain F against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain H against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain C against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7CR3 chain C against the predicted model P0DP25: TM-score 0.55, RMSD 3.12 Å
- 7BYN chain D against the predicted model P0DP25: TM-score 0.55, RMSD 3.58 Å
- 7BYN chain D against the predicted model P0DP25: TM-score 0.55, RMSD 3.58 Å
Elsewhere
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