Research workbench
Structural basis for cholesterol transport-like activity of the hedgehog receptor patched
Analyse Structural basis for cholesterol transport-like activity of the hedgehog… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MG8
- Type
- protein
- Length
- 985 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein patched homolog 1
- UniProt
- Q61115
- Ligands
- CLR
- Pockets
- 9 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 53% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein patched homolog 1 | protein | 985 | 53% helix, 6% strand | Q61115 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.85 | 0.85 | 85 | CLR |
| 2 | 1077 | 0.83 | 0.84 | 98 | CLR |
| 3 | 506 | 0.76 | 0.83 | 84 | empty |
| 4 | 354 | 0.65 | 0.79 | 56 | empty |
| 5 | 403 | 0.64 | 0.78 | 43 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6MG8 · Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched · the same entry in another collection · chain A against A, TM-score 1.00
- Q61115 · AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q61115) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61115
- Elsewhere: RCSB PDB 6MG8 · PDBe 6MG8 · UniProt Q61115
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