UniProt Q61115
Protein patched homolog 1 (Q61115)
Protein patched homolog 1 (UniProt Q61115): 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q61115
- Protein
- Protein patched homolog 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 53 · 4 records with a druggable one
Structures
9 records of Q61115 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6MG8 | Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched | electron microscopy | A | CLR | — |
| 6MG8 | Structural basis for cholesterol transport-like activity of the hedgehog receptor patched | electron microscopy | A | CLR | — |
| 7K65 | Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 | electron microscopy | A | NAG, Q7G | 13 (best 0.84) |
| 7K65 | Hedgehog receptor patched (PTCH1) in complex with conformation selective nanobody TI23 | electron microscopy | A | NAG, Q7G | — |
| 7V6Y | Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed with… | electron microscopy | A | NAG, CLR, 5VI | 9 (best 0.87) |
| 7V6Y | Cryo-EM structure of patched in lipid nanodisc - the wildtype, 3.5 ångström (re-processed with… | electron microscopy | A | NAG, CLR, 5VI | — |
| 7V6Z | Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with… | electron microscopy | A | NAG, CLR | 11 (best 0.82) |
| 7V6Z | Cryo-EM structure of PATCHED1 (V1084A mutant) in lipid nanodisc, 3.64 ångström (reprocessed with… | electron microscopy | A | NAG, CLR | — |
| Q61115 | AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q61115) | predicted | A | — | 20 (best 0.84) |
Ligands
- CLR · Cholesterol · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- 5VI · (2S)-2-azanyl-3-[[(2S)-3-butanoyloxy-2-dec-9-enoyloxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid · in 2 records
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 2 records
Experiment against prediction
- 7V6Y chain A against the predicted model Q61115: TM-score 0.99, RMSD 1.19 Å
- 7V6Y chain A against the predicted model Q61115: TM-score 0.99, RMSD 1.19 Å
- 7K65 chain A against the predicted model Q61115: TM-score 0.99, RMSD 1.29 Å
- 7K65 chain A against the predicted model Q61115: TM-score 0.99, RMSD 1.29 Å
- 6MG8 chain A against the predicted model Q61115: TM-score 0.98, RMSD 1.33 Å
- 6MG8 chain A against the predicted model Q61115: TM-score 0.98, RMSD 1.33 Å
- 7V6Z chain A against the predicted model Q61115: TM-score 0.98, RMSD 1.56 Å
- 7V6Z chain A against the predicted model Q61115: TM-score 0.98, RMSD 1.56 Å
Elsewhere
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