MolNFT v1 · #318297 · protein
AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q61115)
Q61115: “AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q61115)”. 20 pockets (best druggability 0.84). MolNFT v1 #318297 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q61115
- Type
- protein
- Length
- 1,434 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0dDe1C2158EcB65931D4C160486DEFc2f9bC7D1c
- Molecule
- Protein patched homolog 1
- UniProt
- Q61115
- Pockets
- 20 · best druggability 0.84
Structure
1 distinct chain · 42% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein patched homolog 1 | protein | 1434 | 42% helix, 8% strand | Q61115 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 429 | 0.84 | 0.92 | 46 | empty |
| 2 | 153 | 0.79 | 0.95 | 36 | empty |
| 3 | 884 | 0.77 | 0.80 | 69 | empty |
| 4 | 62 | 0.72 | 0.97 | 21 | empty |
| 5 | 204 | 0.62 | 0.83 | 38 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7K65 · Hedgehog receptor patched (PTCH1) in complex with conformation selective nanobody TI23 · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 7K65 · Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 7V6Z · Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 7V6Z · Cryo-EM structure of PATCHED1 (V1084A mutant) in lipid nanodisc, 3.64 ångström… · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 7V6Y · Cryo-EM structure of patched in lipid nanodisc - the wildtype, 3.5 ångström (re-processed… · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 7V6Y · Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed… · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 6MG8 · Structural basis for cholesterol transport-like activity of the hedgehog receptor patched · an experimental structure of the same protein · chain A against A, TM-score 0.68
- 6MG8 · Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched · an experimental structure of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61115
- Elsewhere: UniProt Q61115 · AlphaFold DB Q61115
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