Research workbench
Monophosphorylated PSER33 B-catenin peptide bound to B-TRCP/SKP1 complex
Analyse Monophosphorylated PSER33 B-catenin peptide bound to B-TRCP/SKP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M94
- Type
- protein
- Length
- 544 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-BOX/WD repeat-containing protein 1A; S-phase kinase-associated protein 1; Catenin beta-1
- UniProt
- Q9Y297, P63208, P35222
- Ligands
- PO4
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-BOX/WD repeat-containing protein 1A | protein | 402 | 22% helix, 43% strand | Q9Y297 |
| B | S-phase kinase-associated protein 1 | protein | 133 | 58% helix, 9% strand | P63208 |
| C | Catenin beta-1 | protein | 9 | 0% helix, 0% strand | P35222 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 293 | 0.50 | 0.73 | 36 | PO4 |
Interfaces
2 interfaces between chains.
- A–B · 1430 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 545 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6M94 · Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y297 · AlphaFold monomer V2.0 prediction for F-BOX/WD repeat-containing protein 1A (Q9Y297) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain B against A, TM-score 0.94
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain C against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y297
- Every structure of UniProt P63208
- Every structure of UniProt P35222
- Elsewhere: RCSB PDB 6M94 · PDBe 6M94 · UniProt Q9Y297 · UniProt P63208 · UniProt P35222
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