Research workbench
Crystal structure of the CA2+-free T4L-MICU1-MICU2 complex
Analyse Crystal structure of the CA2+-free T4L-MICU1-MICU2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LB8
- Type
- protein
- Length
- 1,556 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOLYSIN,CALCIUM uptake protein 1, mitochondrial; Calcium uptake protein 2, mitochondrial
- EC
- 3.2.1.17
- UniProt
- D9IEF7, Q9BPX6, Q8IYU8
- Pockets
- 19 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ENDOLYSIN,CALCIUM uptake protein 1, mitochondrial (EC 3.2.1.17) | protein | 462 | 59% helix, 8% strand | D9IEF7, Q9BPX6 |
| B | Calcium uptake protein 2, mitochondrial | protein | 308 | 56% helix, 6% strand | Q8IYU8 |
| C | ENDOLYSIN,CALCIUM uptake protein 1, mitochondrial (EC 3.2.1.17) | protein | 483 | 58% helix, 8% strand | D9IEF7, Q9BPX6 |
| D | Calcium uptake protein 2, mitochondrial | protein | 303 | 58% helix, 8% strand | Q8IYU8 |
Pockets
19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.70 | 0.96 | 14 | empty |
| 2 | 551 | 0.68 | 0.78 | 63 | empty |
| 3 | 609 | 0.66 | 0.76 | 66 | empty |
| 4 | 272 | 0.64 | 0.81 | 29 | empty |
| 5 | 358 | 0.61 | 0.78 | 30 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1090 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 1052 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 722 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 459 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6LB8 · Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q8IYU8 · AlphaFold monomer V2.0 prediction for calcium uptake protein 2, mitochondrial (Q8IYU8) · a predicted model of the same protein · chain D against A, TM-score 0.93
- Q9BPX6 · AlphaFold monomer V2.0 prediction for calcium uptake protein 1, mitochondrial (Q9BPX6) · a predicted model of the same protein · chain C against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D9IEF7
- Every structure of UniProt Q9BPX6
- Every structure of UniProt Q8IYU8
- Elsewhere: RCSB PDB 6LB8 · PDBe 6LB8 · UniProt D9IEF7 · UniProt Q9BPX6 · UniProt Q8IYU8
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