Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with cit , mg and ATP binding at allosteric site.

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• ATP · Adenosine-5'-triphosphate · ligand · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• CIT · Citric acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6L57 · Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT , Mg… · the same entry in another collection · chain A against A, TM-score 1.00
• P51553 · AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NAD] subunit gamma… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P50213 · AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NAD] subunit alpha… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P50213
• Every structure of UniProt P51553
• Elsewhere: RCSB PDB 6L57 · PDBe 6L57 · UniProt P50213 · UniProt P51553