UniProt P51553
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (P51553)
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (UniProt P51553), EC 1.1.1.41: 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 10 pockets. Binding sites, druggability and experiment…
- UniProt
- P51553
- Protein
- Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
- EC
- 1.1.1.41
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 10 · 2 records with a druggable one
Structures
12 records of P51553 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GRE | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+), citrate and… | x-ray diffraction | B | — | — |
| 5GRF | Crystal structure of the alpha gamma mutant (gamma-K151A) of human IDH3 in complex with MG(2+)… | x-ray diffraction | B | — | — |
| 5GRH | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) | x-ray diffraction | B | MG | 6 (best 0.73) |
| 5GRH | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) | x-ray diffraction | B | — | — |
| 5GRI | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) and citrate | x-ray diffraction | B | — | — |
| 5GRL | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), isocitrate… | x-ray diffraction | B | MG, ADP, ICT | 4 (best 0.70) |
| 5GRL | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+), isocitrate… | x-ray diffraction | B | — | — |
| 5YVT | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) and NADH | x-ray diffraction | B | MG, NAI | — |
| 6L57 | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with cit , mg and ATP… | x-ray diffraction | B | MG, ATP | — |
| 6L59 | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with cit, mg and ATP… | x-ray diffraction | B | MG, ATP | — |
| 7CE3 | Crystal structure of human IDH3 holoenzyme in apo form. | x-ray diffraction | B | — | — |
| P51553 | AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6L59 chain B against the predicted model P51553: TM-score 0.99, RMSD 0.63 Å
- 6L57 chain B against the predicted model P51553: TM-score 0.99, RMSD 0.69 Å
- 5GRE chain B against the predicted model P51553: TM-score 0.99, RMSD 0.82 Å
- 5GRI chain B against the predicted model P51553: TM-score 0.99, RMSD 0.90 Å
- 5GRF chain B against the predicted model P51553: TM-score 0.99, RMSD 0.92 Å
- 5GRL chain B against the predicted model P51553: TM-score 0.99, RMSD 0.96 Å
- 5GRL chain B against the predicted model P51553: TM-score 0.99, RMSD 0.96 Å
- 7CE3 chain B against the predicted model P51553: TM-score 0.99, RMSD 0.96 Å
- 5YVT chain B against the predicted model P51553: TM-score 0.99, RMSD 0.92 Å
- 5GRH chain B against the predicted model P51553: TM-score 0.98, RMSD 0.97 Å
Elsewhere
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