UniProt P50213
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (P50213)
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (UniProt P50213), EC 1.1.1.41: 26 experimental structures on GenesisL1, 7 ligands bound, 73 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P50213
- Protein
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- EC
- 1.1.1.41
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 73 · 9 records with a druggable one
Structures
26 records of P50213 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GRE | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), citrate and… | x-ray diffraction | A | MG, ADP | 5 (best 0.71) |
| 5GRE | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+), citrate and… | x-ray diffraction | A | — | — |
| 5GRF | Crystal structure of the alpha gamma mutant (gamma-K151A) of human IDH3 in complex with MG(2+)… | x-ray diffraction | A | — | — |
| 5GRH | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) | x-ray diffraction | A | MG | 6 (best 0.73) |
| 5GRH | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) | x-ray diffraction | A | — | — |
| 5GRI | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) and citrate | x-ray diffraction | A | — | — |
| 5GRL | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), isocitrate… | x-ray diffraction | A | MG, ADP, ICT | 5 (best 0.70) |
| 5GRL | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+), isocitrate… | x-ray diffraction | A | — | — |
| 5YVT | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with MG(2+) and NADH | x-ray diffraction | A | MG, NAI | — |
| 6KDE | Crystal structure of the alpha beta heterodimer of human IDH3 in complex with Ca(2+) | x-ray diffraction | A, C | CA | — |
| 6KDE | Crystal structure of the alpha beta heterodimer of human IDH3 in complex with CA(2+) | x-ray diffraction | A, C | CA | — |
| 6KDF | Crystal structure of the alpha beta heterodimer of human IDH3 in APO form. | x-ray diffraction | B, A, E, G, I, K, M, O | — | — |
| 6KDF | Crystal structure of the alpha beta heterodimer of human IDH3 in apo form. | x-ray diffraction | B, A, E, G, I, K, M, O | — | — |
| 6KDY | Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NAD. | x-ray diffraction | A, C, E, G | NAD | — |
| 6KDY | Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NAD. | x-ray diffraction | A, C, E, G | NAD | — |
| 6KE3 | Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NADH | x-ray diffraction | A, C, E, G | NAI | — |
| 6L57 | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with cit , mg and ATP… | x-ray diffraction | A | MG, ATP | — |
| 6L59 | Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with cit, mg and ATP… | x-ray diffraction | A | ATP, MG | — |
| 7CE3 | Crystal structure of human IDH3 holoenzyme in apo form. | x-ray diffraction | A, C | — | — |
| 8GRB | Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 | x-ray diffraction | B, A, E, G, I, K, M, O | — | 20 (best 0.76) |
| 8GRD | Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in… | x-ray diffraction | A | MG, ADP | 3 (best 0.73) |
| 8GRG | Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3 | x-ray diffraction | A | — | 4 (best 0.77) |
| 8GRH | Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3 in… | x-ray diffraction | A | — | 4 (best 0.71) |
| 8GRU | Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in… | x-ray diffraction | A, C | NAD, CA, ICT | 11 (best 0.73) |
| 8GS5 | Crystal structure of a constitutively active mutant of human IDH3 holoenzyme in apo form | x-ray diffraction | C, A, G, E, K, I, O, M | — | 15 (best 0.78) |
| P50213 | AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial… | — | — | — |
Ligands
- MG · Magnesium ion · in 7 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- CA · Calcium ion · in 3 records
- NAD · Nicotinamide-adenine-dinucleotide · in 3 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- ICT · Isocitric acid · in 2 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 2 records
Elsewhere
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