LSD1/CO-rest structure with an inhibitor

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• CW0 · piperidin-4-ylmethyl 4-fluoranyl-4-[[[(1~{R},2~{S})-2-phenylcyclopropyl]amino]methyl]piperidine-1-carboxylate · ligand · chains A
• D3U · 2-PCPA derivative · ligand · chains A
• CVO · Piperidin-4-ylmethyl 4-(aminomethyl)-4-fluoranyl-piperidine-1-carboxylate · ligand · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · 12 copies · chains A
• GOL · Glycerol · additive · 4 copies · chains A
• MLA · Malonic acid · additive · 3 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
• ACT · Acetate ion · additive · 2 copies · chains A, B
• DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6K3E · LSD1/Co-Rest structure with an inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UKL0 · AlphaFold monomer V2.0 prediction for rest corepressor 1 (Q9UKL0) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60341
• Every structure of UniProt Q9UKL0
• Elsewhere: RCSB PDB 6K3E · PDBe 6K3E · UniProt O60341 · UniProt Q9UKL0