UniProt O60341
Lysine-specific histone demethylase 1A (O60341)
Lysine-specific histone demethylase 1A (UniProt O60341), EC 1.-.-.-, 1.14.99.66: 164 experimental structures on GenesisL1, 39 ligands bound, 191 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O60341
- Protein
- Lysine-specific histone demethylase 1A
- EC
- 1.-.-.-, 1.14.99.66
- Experimental structures
- 164
- Predicted models
- 0
- Ligands
- 39
- Pockets
- 191 · 23 records with a druggable one
Structures
164 records of O60341 in the MolNFT archive: 164 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2COM | The solution structure of the SWIRM domain of human LSD1 | solution nmr | A | — | — |
| 2COM | The solution structure of the swirm domain of human LSD1 | solution nmr | A | — | — |
| 2DW4 | Crystal structure of human LSD1 at 2.3 A resolution | x-ray diffraction | A | — | — |
| 2DW4 | Crystal structure of human LSD1 at 2.3 a resolution | x-ray diffraction | A | — | — |
| 2EJR | LSD1-tranylcypromine complex | x-ray diffraction | A | — | — |
| 2EJR | LSD1-tranylcypromine complex | x-ray diffraction | A | — | — |
| 2H94 | Crystal Structure and Mechanism of human Lysine-Specific Demethylase-1 | x-ray diffraction | A | — | — |
| 2H94 | Crystal structure and mechanism of human lysine-specific demethylase-1 | x-ray diffraction | A | — | — |
| 2HKO | Crystal structure of LSD1 | x-ray diffraction | A | — | — |
| 2HKO | Crystal structure of LSD1 | x-ray diffraction | A | — | — |
| 2IW5 | Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone… | x-ray diffraction | A | — | — |
| 2IW5 | Structural basis for corest-dependent demethylation of nucleosomes by the human LSD1 histone… | x-ray diffraction | A | — | — |
| 2L3D | The solution structure of the short form SWIRM domain of LSD1 | solution nmr | A | — | — |
| 2L3D | The solution structure of the short form swirm domain of LSD1 | solution nmr | A | — | — |
| 2UXN | Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation | x-ray diffraction | A | — | — |
| 2UXN | Structural basis of histone demethylation by LSD1 revealed by suicide inactivation | x-ray diffraction | A | — | — |
| 2UXX | Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct | x-ray diffraction | A | — | — |
| 2UXX | Human LSD1 histone demethylase-corest in complex with an FAD- tranylcypromine adduct | x-ray diffraction | A | — | — |
| 2V1D | Structural basis of LSD1-CoREST selectivity in histone H3 recognition | x-ray diffraction | A | — | — |
| 2V1D | Structural basis of LSD1-corest selectivity in histone H3 recognition | x-ray diffraction | A | — | — |
| 2X0L | Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. | x-ray diffraction | A | — | — |
| 2X0L | Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. | x-ray diffraction | A | — | — |
| 2XAF | Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAF | Crystal structure of LSD1-corest in complex with para-bromo- (+)-cis-2-phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAG | Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAG | Crystal structure of LSD1-corest in complex with para-bromo- (-)-trans-2-phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAH | Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAH | Crystal structure of LSD1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAJ | Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAJ | Crystal structure of LSD1-corest in complex with (-)-trans- 2-phenylcyclopropyl-1-amine | x-ray diffraction | A | — | — |
| 2XAQ | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) | x-ray diffraction | A | — | — |
| 2XAQ | Crystal structure of LSD1-corest in complex with a tranylcypromine derivative (MC2584, 13B) | x-ray diffraction | A | — | — |
| 2XAS | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) | x-ray diffraction | A | — | — |
| 2XAS | Crystal structure of LSD1-corest in complex with a tranylcypromine derivative (MC2580, 14E) | x-ray diffraction | A | — | — |
| 2Y48 | Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide | x-ray diffraction | A | — | — |
| 2Y48 | Crystal structure of LSD1-corest in complex with a N- terminal snail peptide | x-ray diffraction | A | — | — |
| 2Z3Y | Crystal structure of Lysine-specific demethylase1 | x-ray diffraction | A | — | — |
| 2Z3Y | Crystal structure of lysine-specific DEMETHYLASE1 | x-ray diffraction | A | — | — |
| 2Z5U | Crystal structure of Lysine-specific histone demethylase 1 | x-ray diffraction | A | — | — |
| 2Z5U | Crystal structure of lysine-specific histone demethylase 1 | x-ray diffraction | A | — | — |
| 3ABT | Crystal Structure of LSD1 in complex with trans-2-pentafluorophenylcyclopropylamine | x-ray diffraction | A | — | — |
| 3ABT | Crystal structure of LSD1 in complex with trans-2- pentafluorophenylcyclopropylamine | x-ray diffraction | A | — | — |
| 3ABU | Crystal Structure of LSD1 in complex with a 2-PCPA derivative, S1201 | x-ray diffraction | A | — | — |
| 3ABU | Crystal structure of LSD1 in complex with a 2-pcpa derivative, S1201 | x-ray diffraction | A | — | — |
| 3ZMS | LSD1-CoREST in complex with INSM1 peptide | x-ray diffraction | A | — | — |
| 3ZMS | LSD1-corest in complex with INSM1 peptide | x-ray diffraction | A | — | — |
| 3ZMT | LSD1-CoREST in complex with PRSFLV peptide | x-ray diffraction | A | — | — |
| 3ZMT | LSD1-corest in complex with prsflv peptide | x-ray diffraction | A | — | — |
| 3ZMU | LSD1-CoREST in complex with PKSFLV peptide | x-ray diffraction | A | — | — |
| 3ZMU | LSD1-corest in complex with pksflv peptide | x-ray diffraction | A | — | — |
| 3ZMV | LSD1-CoREST in complex with PLSFLV peptide | x-ray diffraction | A | — | — |
| 3ZMV | LSD1-corest in complex with plsflv peptide | x-ray diffraction | A | — | — |
| 3ZMZ | LSD1-CoREST in complex with PRSFAV peptide | x-ray diffraction | A | — | — |
| 3ZMZ | LSD1-corest in complex with prsfav peptide | x-ray diffraction | A | — | — |
| 3ZN0 | LSD1-CoREST in complex with PRSFAA peptide | x-ray diffraction | A | — | — |
| 3ZN0 | LSD1-corest in complex with prsfaa peptide | x-ray diffraction | A | — | — |
| 3ZN1 | LSD1-CoREST in complex with PRLYLV peptide | x-ray diffraction | A | — | — |
| 3ZN1 | LSD1-corest in complex with prlylv peptide | x-ray diffraction | A | — | — |
| 4BAY | Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST | x-ray diffraction | A | — | — |
| 4BAY | Phosphomimetic mutant of LSD1-8A splicing variant in complex with corest | x-ray diffraction | A | — | — |
104 records more on the page itself.
Ligands
- FAD · Flavin-adenine dinucleotide · in 60 records
- DJ0 · 3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal · in 9 records
- 7UQ · 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl) methoxy]phenyl]propanal · in 3 records
- CL · Chloride ion · in 3 records
- DJC · 3-[4-[5-fluoranyl-2-(trifluoromethyl) phenyl]phenyl]propanal · in 3 records
- MG · Magnesium ion · in 3 records
- NA · Sodium ion · in 3 records
- 6W1 · 4-methyl-~{N}-[2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide · in 2 records
- 6W3 · 4-methyl-~{N}-[2-[[4-(1-methylpiperidin-4-yl) oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide · in 2 records
- 6X0 · 4-ethyl-~{N}-[3-(methoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide · in 2 records
- 6X3 · 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl) oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide · in 2 records
- 767 · N2-(3-(dimethylamino)propyl)-6,7-dimethoxy-N4,N4-dimethylquinazoline-2,4-diamine · in 2 records
- CW0 · piperidin-4-ylmethyl 4-fluoranyl-4-[[[(1~{R},2~{S})-2-phenylcyclopropyl]amino]methyl]piperidine-1-carboxylate · in 2 records
- D3U · 2-PCPA derivative · in 2 records
- E11 · N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino) propyl]-6,7-dimethoxyquinazoline-2,4-diamine · in 2 records
- SO4 · Sulfate ion · in 2 records
- V0Y · 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile · in 2 records
- Y0Z · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[7,8-dimethyl-2,4-dioxo-5-{3-[3-(phenylcarbamoyl)phenyl]propanoyl}-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate · in 2 records
- 6F5 · 6-methylheptanoic acid · in 1 record
- 6FH · (6~{S})-6-methyloctanoic acid · in 1 record
- 6W0 · ~{N}-[3-(methoxymethyl)phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide · in 1 record
- 6X5 · ~{N}-[3-(ethoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide · in 1 record
- 7UW · 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-4-yl) methoxy]phenyl]propanal · in 1 record
- 8A2 · 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal · in 1 record
- 8WC · 4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrile · in 1 record
- A1IG2 · Bomedemstat FAD adduct · in 1 record
- CVO · Piperidin-4-ylmethyl 4-(aminomethyl)-4-fluoranyl-piperidine-1-carboxylate · in 1 record
- FA8 · [[(2R,3S,4S)-5-[(4AS)-7,8-dimethyl-2,4-dioxo-4A,5-dihydrobenzo[g]pteridin-10-yl]-2,3,4-trihydroxy-pentoxy]-hydroxy-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- HUF · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate · in 1 record
- I00 · ~{N}-(oxan-4-yl)-5-(3-oxidanylidenepropyl)thiophene-3-carboxamide · in 1 record
Elsewhere
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