UniProt Q9UKL0
REST corepressor 1 (Q9UKL0)
REST corepressor 1 (UniProt Q9UKL0): 147 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 173 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UKL0
- Protein
- REST corepressor 1
- Experimental structures
- 147
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 173 · 5 records with a druggable one
Structures
148 records of Q9UKL0 in the MolNFT archive: 147 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IW5 | Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone… | x-ray diffraction | B | — | — |
| 2IW5 | Structural basis for corest-dependent demethylation of nucleosomes by the human LSD1 histone… | x-ray diffraction | B | — | — |
| 2UXN | Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation | x-ray diffraction | B | — | — |
| 2UXN | Structural basis of histone demethylation by LSD1 revealed by suicide inactivation | x-ray diffraction | B | — | — |
| 2UXX | Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct | x-ray diffraction | B | — | — |
| 2UXX | Human LSD1 histone demethylase-corest in complex with an FAD- tranylcypromine adduct | x-ray diffraction | B | — | — |
| 2V1D | Structural basis of LSD1-CoREST selectivity in histone H3 recognition | x-ray diffraction | B | — | — |
| 2V1D | Structural basis of LSD1-corest selectivity in histone H3 recognition | x-ray diffraction | B | — | — |
| 2X0L | Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. | x-ray diffraction | B | — | — |
| 2X0L | Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. | x-ray diffraction | B | — | — |
| 2XAF | Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAF | Crystal structure of LSD1-corest in complex with para-bromo- (+)-cis-2-phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAG | Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAG | Crystal structure of LSD1-corest in complex with para-bromo- (-)-trans-2-phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAH | Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAH | Crystal structure of LSD1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAJ | Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAJ | Crystal structure of LSD1-corest in complex with (-)-trans- 2-phenylcyclopropyl-1-amine | x-ray diffraction | B | — | — |
| 2XAQ | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) | x-ray diffraction | B | — | — |
| 2XAQ | Crystal structure of LSD1-corest in complex with a tranylcypromine derivative (MC2584, 13B) | x-ray diffraction | B | — | — |
| 2XAS | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) | x-ray diffraction | B | — | — |
| 2XAS | Crystal structure of LSD1-corest in complex with a tranylcypromine derivative (MC2580, 14E) | x-ray diffraction | B | — | — |
| 2Y48 | Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide | x-ray diffraction | B | — | — |
| 2Y48 | Crystal structure of LSD1-corest in complex with a N- terminal snail peptide | x-ray diffraction | B | — | — |
| 3ZMS | LSD1-CoREST in complex with INSM1 peptide | x-ray diffraction | B | — | — |
| 3ZMS | LSD1-corest in complex with INSM1 peptide | x-ray diffraction | B | — | — |
| 3ZMT | LSD1-CoREST in complex with PRSFLV peptide | x-ray diffraction | B | — | — |
| 3ZMT | LSD1-corest in complex with prsflv peptide | x-ray diffraction | B | — | — |
| 3ZMU | LSD1-CoREST in complex with PKSFLV peptide | x-ray diffraction | B | — | — |
| 3ZMU | LSD1-corest in complex with pksflv peptide | x-ray diffraction | B | — | — |
| 3ZMV | LSD1-CoREST in complex with PLSFLV peptide | x-ray diffraction | B | — | — |
| 3ZMV | LSD1-corest in complex with plsflv peptide | x-ray diffraction | B | — | — |
| 3ZMZ | LSD1-CoREST in complex with PRSFAV peptide | x-ray diffraction | B | — | — |
| 3ZMZ | LSD1-corest in complex with prsfav peptide | x-ray diffraction | B | — | — |
| 3ZN0 | LSD1-CoREST in complex with PRSFAA peptide | x-ray diffraction | B | — | — |
| 3ZN0 | LSD1-corest in complex with prsfaa peptide | x-ray diffraction | B | — | — |
| 3ZN1 | LSD1-CoREST in complex with PRLYLV peptide | x-ray diffraction | B | — | — |
| 3ZN1 | LSD1-corest in complex with prlylv peptide | x-ray diffraction | B | — | — |
| 4BAY | Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST | x-ray diffraction | B | — | — |
| 4BAY | Phosphomimetic mutant of LSD1-8A splicing variant in complex with corest | x-ray diffraction | B | — | — |
| 4UV8 | LSD1(KDM1A)-CoREST in complex with 1-Benzyl-Tranylcypromine | x-ray diffraction | B | — | — |
| 4UV8 | LSD1(KDM1A)-corest in complex with 1-benzyl-tranylcypromine | x-ray diffraction | B | — | — |
| 4UV9 | LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine | x-ray diffraction | B | — | — |
| 4UV9 | LSD1(KDM1A)-corest in complex with 1-ethyl-tranylcypromine | x-ray diffraction | B | — | — |
| 4UVA | LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S) | x-ray diffraction | B | — | — |
| 4UVA | LSD1(KDM1A)-corest in complex with 1-methyl-tranylcypromine (1R,2S) | x-ray diffraction | B | — | — |
| 4UVB | LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R) | x-ray diffraction | B | — | — |
| 4UVB | LSD1(KDM1A)-corest in complex with 1-methyl-tranylcypromine (1S,2R) | x-ray diffraction | B | — | — |
| 4UVC | LSD1(KDM1A)-CoREST in complex with 1-Phenyl-Tranylcypromine | x-ray diffraction | B | — | — |
| 4UVC | LSD1(KDM1A)-corest in complex with 1-phenyl-tranylcypromine | x-ray diffraction | B | — | — |
| 4UXN | LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580 | x-ray diffraction | B | — | — |
| 4UXN | LSD1(KDM1A)-corest in complex with Z-pro derivative of MC2580 | x-ray diffraction | B | — | — |
| 4XBF | Structure of LSD1:CoREST in complex with ssRNA | x-ray diffraction | B | — | 4 (best 0.38) |
| 4XBF | Structure of LSD1:COREST in complex with ssrna | x-ray diffraction | B | — | — |
| 5H6Q | Crystal structure of LSD1-CoREST in complex with peptide 11 | x-ray diffraction | B | — | 1 (best 0.30) |
| 5H6Q | Crystal structure of LSD1-corest in complex with peptide 11 | x-ray diffraction | B | — | — |
| 5H6R | Crystal structure of LSD1-CoREST in complex with peptide 13 | x-ray diffraction | B | — | — |
| 5H6R | Crystal structure of LSD1-corest in complex with peptide 13 | x-ray diffraction | B | — | — |
| 5L3B | Human LSD1/CoREST: LSD1 D556G mutation | x-ray diffraction | B | — | — |
| 5L3B | Human LSD1/COREST: LSD1 D556G mutation | x-ray diffraction | B | — | — |
88 records more on the page itself.
Ligands
Experiment against prediction
- 5X60 chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.63 Å
- 5X60 chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.63 Å
- 2V1D chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.68 Å
- 2V1D chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.68 Å
- 5H6R chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.68 Å
- 5H6R chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.68 Å
- 8Q1G chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.69 Å
- 5H6Q chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.70 Å
- 5H6Q chain B against the predicted model Q9UKL0: TM-score 0.98, RMSD 0.70 Å
- 2IW5 chain B against the predicted model Q9UKL0: TM-score 0.97, RMSD 0.70 Å
Elsewhere
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