Research workbench
Crystal structure of the human RAD9-HUS1-RAD1-rhino complex
Analyse Crystal structure of the human RAD9-HUS1-RAD1-rhino complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6J8Y
- Type
- protein
- Length
- 786 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell cycle checkpoint control protein RAD9A; Checkpoint protein HUS1; Cell cycle…
- EC
- 3.1.11.2
- UniProt
- Q99638, O60921, O60671, Q9BSD3
- Pockets
- 9 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 19% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell cycle checkpoint control protein RAD9A (EC 3.1.11.2) | protein | 257 | 22% helix, 42% strand | Q99638 |
| B | Checkpoint protein HUS1 | protein | 264 | 22% helix, 44% strand | O60921 |
| C | Cell cycle checkpoint protein RAD1 (EC 3.1.11.2) | protein | 255 | 15% helix, 49% strand | O60671 |
| D | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | protein | 10 | 0% helix, 0% strand | Q9BSD3 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.81 | 0.98 | 20 | empty |
| 2 | 78 | 0.59 | 0.88 | 19 | empty |
| 3 | 59 | 0.55 | 0.88 | 16 | empty |
| 4 | 85 | 0.49 | 0.83 | 21 | empty |
| 5 | 69 | 0.41 | 0.80 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–C · 723 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 712 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 696 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 603 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6J8Y · Crystal structure of the human RAD9-HUS1-RAD1-RHINO complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q99638 · AlphaFold monomer V2.0 prediction for cell cycle checkpoint control protein RAD9A (Q99638) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O60671 · AlphaFold monomer V2.0 prediction for cell cycle checkpoint protein RAD1 (O60671) · a predicted model of the same protein · chain C against A, TM-score 0.99
- O60921 · AlphaFold monomer V2.0 prediction for checkpoint protein HUS1 (O60921) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q9BSD3 · AlphaFold monomer V2.0 prediction for RAD9, HUS1, RAD1-interacting nuclear orphan protein… · a predicted model of the same protein · chain D against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99638
- Every structure of UniProt O60921
- Every structure of UniProt O60671
- Every structure of UniProt Q9BSD3
- Elsewhere: RCSB PDB 6J8Y · PDBe 6J8Y · UniProt Q99638 · UniProt O60921 · UniProt O60671 · UniProt Q9BSD3
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