Research workbench
Solution structure of CAM/KV7.2-hab complex
Analyse Solution structure of CAM/KV7.2-hab complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FEG
- Type
- protein
- Length
- 263 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily kqt member 2, potassium voltage-gated channel…
- UniProt
- O43526, P0DP23
- Ligands
- CA
- Pockets
- 4 · best druggability 0.63
Structure
solution nmr · 2 distinct chains · 50% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium voltage-gated channel subfamily kqt member 2, potassium voltage-gated channel subfamily kqt member 2 | protein | 115 | 47% helix, 0% strand | O43526 |
| B | Calmodulin-1 | protein | 148 | 53% helix, 4% strand | P0DP23 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.63 | 0.84 | 24 | empty |
| 2 | 164 | 0.58 | 0.82 | 20 | empty |
| 3 | 92 | 0.54 | 0.84 | 17 | empty |
| 4 | 120 | 0.47 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2182 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6FEG · Solution Structure of CaM/Kv7.2-hAB Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain B against A, TM-score 0.52
- O43526 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43526
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 6FEG · PDBe 6FEG · UniProt O43526 · UniProt P0DP23
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