Research workbench
Undecorated gmpcpp microtubule
Analyse Undecorated gmpcpp microtubule in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DPU
- Type
- protein
- Length
- 5,142 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin alpha-1B chain; Tubulin beta chain
- UniProt
- Q2XVP4, P02554
- Ligands
- GTP, G2P, MG
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 49% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, J, K, L | Tubulin alpha-1B chain | protein | 430 | 48% helix, 17% strand | Q2XVP4 |
| B, D, F, G, H, I | Tubulin beta chain | protein | 427 | 50% helix, 20% strand | P02554 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 6 copies · chains A, H, C, I, E, G, F, J, B, K, D, L
- G2P · Phosphomethylphosphonic acid guanylate ester · ligand · 6 copies · chains A, B, C, D, E, F, G, H, I
- MG · Magnesium ion · metal · 12 copies · chains A, B, C, D, E, G, F, H, I, J, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 261 | 0.84 | 0.96 | 43 | GTP, MG |
| 2 | 255 | 0.84 | 0.96 | 41 | GTP, MG |
| 3 | 253 | 0.84 | 0.96 | 41 | GTP, MG |
| 4 | 263 | 0.83 | 0.95 | 43 | GTP, MG |
| 5 | 256 | 0.83 | 0.95 | 41 | GTP, MG |
Interfaces
17 interfaces between chains.
- B–K · 1960 Ų buried · 17 hydrogen bonds · protein-protein
- F–J · 1957 Ų buried · 17 hydrogen bonds · protein-protein
- E–G · 1955 Ų buried · 17 hydrogen bonds · protein-protein
- D–L · 1955 Ų buried · 17 hydrogen bonds · protein-protein
- A–H · 1955 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6DPU · Undecorated GMPCPP microtubule · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2XVP4
- Every structure of UniProt P02554
- Elsewhere: RCSB PDB 6DPU · PDBe 6DPU · UniProt Q2XVP4 · UniProt P02554
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