Structure of rifampicin monooxygenase with product bound

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).

Ligands and binding sites

• FAD · Flavin-adenine dinucleotide · ligand · chains A
• RFH · (1E,3S,4R,5S,6R,7R,8R,9S,10S,11E,13E)-15-amino-1-{[(2S)-5,7-dihydroxy-2,4-dimethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,6,9-trioxo-1,2,6, 9-tetrahydronaphtho[2,1-b]furan-2-yl]oxy}-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxopentadeca-1,11,13-trien-5-yl acetate · ligand · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 6C7S · Structure of Rifampicin Monooxygenase with Product Bound · the same entry in another collection · chain A against A, TM-score 1.00
• Q5YTV5 · AlphaFold monomer V2.0 prediction for rifampicin monooxygenase (Q5YTV5) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q5YTV5
• Elsewhere: RCSB PDB 6C7S · PDBe 6C7S · UniProt Q5YTV5