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Ligand · RFH

RFH · (1E,3S,4R,5S,6R,7R,8R,9S,10S,11E,13E)-15-amino-1-{[(2S)-5,7-dihydroxy-2,4-dimethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,6,9-trioxo-1,2,6, 9-tetrahydronaphtho[2,1-b]furan-2-yl]oxy}-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxopentadeca-1,11,13-trien-5-yl acetate

RFH, (1E,3S,4R,5S,6R,7R,8R,9S,10S,11E,13E)-15-amino-1-{[(2S)-5,7-dihydroxy-2,4-dimethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,6,9-trioxo-1,2,6…

Component
RFH
Formula
C43 H58 N4 O13
Class
ligand
Structures
2
PDB entries
1

Binding sites

RFH in 2 structures; the first of them:

  • 6C7S · Structure of Rifampicin Monooxygenase with Product Bound · RFH A502 · binds ARG43, VAL71, GLY72, GLY73, PHE74, ALA76, GLY77, ALA95 and 14 more
  • 6C7S · Structure of rifampicin monooxygenase with product bound · RFH A502 · binds ARG43, VAL71, GLY72, GLY73, PHE74, ALA76, GLY77, ALA95 and 14 more

Residues it binds most

GLY 2, ARG 2, LEU 2, PHE 2, ALA 2, ILE 2, MET 2, PRO 2, THR 2, VAL 2 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

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