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Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the plp-L-serine intermediate
Analyse Crystal structures of cystathionine beta-synthase from saccharomyces… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C2Q
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cystathionine beta-synthase
- EC
- 4.2.1.22
- UniProt
- P32582
- Ligands
- EVM, CA, NA, CL
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cystathionine beta-synthase (EC 4.2.1.22) | protein | 345 | 42% helix, 17% strand | P32582 |
Ligands and binding sites
- EVM · L-Serine, N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene] · ligand · chains A
- CA · Calcium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
- PGE · Triethylene glycol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.76 | 0.98 | 29 | EVM |
| 2 | 168 | 0.64 | 0.85 | 28 | CL |
| 3 | 92 | 0.35 | 0.74 | 14 | PGE |
Compared structures
- 6C2Q · Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the… · the same entry in another collection · chain A against A, TM-score 1.00
- P32582 · AlphaFold monomer V2.0 prediction for cystathionine beta-synthase (P32582) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32582
- Elsewhere: RCSB PDB 6C2Q · PDBe 6C2Q · UniProt P32582
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