Research workbench
Crystal structure of SAP/FYNSH3/SLAM ternary complex
Analyse Crystal structure of SAP/FYNSH3/SLAM ternary complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M27
- Type
- protein
- Length
- 176 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SH2 domain protein 1A; Signaling lymphocytic activation molecule; Proto-oncogene…
- EC
- 2.7.1.112
- UniProt
- O60880, Q13291, P06241
Structure
x-ray diffraction · 3 distinct chains · 12% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SH2 domain protein 1A | protein | 104 | 17% helix, 30% strand | O60880 |
| B | Signaling lymphocytic activation molecule | protein | 11 | 0% helix, 36% strand | Q13291 |
| C | Proto-oncogene tyrosine-protein kinase fyn (EC 2.7.1.112) | protein | 61 | 5% helix, 44% strand | P06241 |
Ligands and binding sites
- FLC · Citrate anion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
2 interfaces between chains.
- A–B · 830 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 431 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1M27 · Crystal structure of SAP/FynSH3/SLAM ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
- O60880 · AlphaFold monomer V2.0 prediction for SH2 domain-containing protein 1A (O60880) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q13291 · AlphaFold monomer V2.0 prediction for signaling lymphocytic activation molecule (Q13291) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60880
- Every structure of UniProt Q13291
- Every structure of UniProt P06241
- Elsewhere: RCSB PDB 1M27 · PDBe 1M27 · UniProt O60880 · UniProt Q13291 · UniProt P06241
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