UniProt P06241
Tyrosine-protein kinase Fyn (P06241)
Tyrosine-protein kinase Fyn (UniProt P06241), EC 2.7.10.2: 86 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P06241
- Protein
- Tyrosine-protein kinase Fyn
- EC
- 2.7.10.2
- Experimental structures
- 86
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 0 records with a druggable one
Structures
87 records of P06241 in the MolNFT archive: 86 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A0N | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase complexed with the synthetic… | solution nmr | B | — | — |
| 1A0N | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase complexed with the synthetic… | solution nmr | B | — | — |
| 1AOT | NMR structure of the fyn SH2 domain complexed with a phosphotyrosyl peptide, minimized average… | solution nmr | F | — | — |
| 1AOT | NMR structure of the fyn SH2 domain complexed with a phosphotyrosyl peptide, minimized average… | solution nmr | F | — | — |
| 1AOU | NMR structure of the fyn SH2 domain complexed with a phosphotyrosyl peptide, 22 structures | solution nmr | F | — | — |
| 1AOU | NMR structure of the fyn SH2 domain complexed with a phosphotyrosyl peptide, 22 structures | solution nmr | F | — | — |
| 1AVZ | V-1 nef protein in complex with wild type fyn SH3 domain | x-ray diffraction | C | — | — |
| 1AVZ | V-1 nef protein in complex with wild type fyn SH3 domain | x-ray diffraction | C | — | — |
| 1AZG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase kinase complexed with the… | solution nmr | B | — | — |
| 1AZG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase kinase complexed with the… | solution nmr | B | — | — |
| 1EFN | HIV-1 nef protein in complex with R96I mutant fyn SH3 domain | x-ray diffraction | A, C | — | — |
| 1EFN | HIV-1 nef protein in complex with R96I mutant fyn SH3 domain | x-ray diffraction | A, C | — | — |
| 1FYN | Phosphotransferase | x-ray diffraction | A | — | — |
| 1FYN | Phosphotransferase | x-ray diffraction | A | — | — |
| 1G83 | Crystal structure of fyn SH3-SH2 | x-ray diffraction | A, B | — | — |
| 1G83 | Crystal structure of fyn SH3-SH2 | x-ray diffraction | A, B | — | — |
| 1M27 | Crystal structure of SAP/FynSH3/SLAM ternary complex | x-ray diffraction | C | — | — |
| 1M27 | Crystal structure of SAP/FYNSH3/SLAM ternary complex | x-ray diffraction | C | — | — |
| 1NYF | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase, minimized average (probmap)… | solution nmr | A | — | — |
| 1NYF | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase, minimized average (probmap)… | solution nmr | A | — | — |
| 1NYG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase, family of 20 structures | solution nmr | A | — | — |
| 1NYG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase, family of 20 structures | solution nmr | A | — | — |
| 1SHF | Crystal structure of the SH3 domain in human fyn; comparison of the three-dimensional structures of… | x-ray diffraction | A, B | — | — |
| 1SHF | Crystal structure of the SH3 domain in human fyn; comparison of the three-dimensional structures of… | x-ray diffraction | A, B | — | — |
| 1ZBJ | Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched… | solution nmr | A | — | — |
| 1ZBJ | Inferential structure determination of the fyn SH3 domain using noesy data from a 15N,H2 enriched… | solution nmr | A | — | — |
| 2DQ7 | Crystal Structure of Fyn kinase domain complexed with staurosporine | x-ray diffraction | X | — | — |
| 2DQ7 | Crystal structure of fyn kinase domain complexed with staurosporine | x-ray diffraction | X | — | — |
| 2MQI | human Fyn SH2 free state | solution nmr | A | — | — |
| 2MQI | Human fyn SH2 free state | solution nmr | A | — | — |
| 2MRJ | Structure of Fyn protein SH2 bound | solution nmr | A | — | — |
| 2MRJ | Structure of fyn protein SH2 bound | solution nmr | A | — | — |
| 2MRK | Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide | solution nmr | A, B | — | — |
| 2MRK | Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide | solution nmr | A, B | — | — |
| 3H0F | Crystal structure of the human Fyn SH3 R96W mutant | x-ray diffraction | A | — | — |
| 3H0F | Crystal structure of the human fyn SH3 R96W mutant | x-ray diffraction | A | — | — |
| 3H0H | human Fyn SH3 domain R96I mutant, crystal form I | x-ray diffraction | A | — | — |
| 3H0H | Human fyn SH3 domain R96I mutant, crystal form I | x-ray diffraction | A | — | — |
| 3H0I | human Fyn SH3 domain R96I mutant, crystal form II | x-ray diffraction | A, B | — | — |
| 3H0I | Human fyn SH3 domain R96I mutant, crystal form II | x-ray diffraction | A, B | — | — |
| 3UA6 | Crystal Structure of the Human Fyn SH3 domain | x-ray diffraction | A, B | — | — |
| 3UA6 | Crystal structure of the human fyn SH3 domain | x-ray diffraction | A, B | — | — |
| 3UA7 | Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus… | x-ray diffraction | A, B, C, D | — | — |
| 3UA7 | Crystal structure of the human fyn SH3 domain in complex with a peptide from the hepatitis C virus… | x-ray diffraction | A, B, C, D | — | — |
| 4D8D | Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant | x-ray diffraction | A, C | — | — |
| 4D8D | Crystal structure of HIV-1 nef fyn-SH3 R96W variant | x-ray diffraction | A, C | — | — |
| 4EIK | Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 | x-ray diffraction | A | — | — |
| 4EIK | Crystal structure of the human fyn SH3 domain in complex with the synthetic peptide VSL12 | x-ray diffraction | A | — | — |
| 4U17 | Swapped dimer of the human Fyn-SH2 domain | x-ray diffraction | A, B, C | — | — |
| 4U17 | Swapped dimer of the human fyn-SH2 domain | x-ray diffraction | A, B, C | — | — |
| 4U1P | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | x-ray diffraction | A | — | — |
| 4U1P | Human fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | x-ray diffraction | A | — | — |
| 4ZNX | Crystal structure of the Fyn-SH3 domain in complex with the high affinity peptide APP12 | x-ray diffraction | A, B, C, D | — | — |
| 4ZNX | Crystal structure of the fyn-SH3 domain in complex with the high affinity peptide APP12 | x-ray diffraction | A, B, C, D | — | — |
| 5ZAU | Complex of the human FYN SH3 and monobody binder | solution nmr | A | — | — |
| 5ZAU | Complex of the human fyn SH3 and monobody binder | solution nmr | A | — | — |
| 6IPY | His-tagged fyn SH3 domain R96I mutant | x-ray diffraction | A | — | — |
| 6IPZ | Fyn SH3 domain R96W mutant, crystallized with 18-crown-6 | x-ray diffraction | Z | O4B | — |
| 7A2J | Crystal structure of the Fyn SH3 domain in space group C21 at pH 7.5 | x-ray diffraction | A, B | NA | 1 (best 0.28) |
| 7A2J | Crystal structure of the fyn SH3 domain in space group C21 at pH 7.5 | x-ray diffraction | A, B | NA | — |
27 records more on the page itself.
Ligands
Experiment against prediction
- 3UA7 chain C against the predicted model P06241: TM-score 0.98, RMSD 0.43 Å
- 3UA7 chain C against the predicted model P06241: TM-score 0.98, RMSD 0.43 Å
- 7A2P chain A against the predicted model P06241: TM-score 0.97, RMSD 0.49 Å
- 7A2P chain A against the predicted model P06241: TM-score 0.97, RMSD 0.49 Å
- 4ZNX chain B against the predicted model P06241: TM-score 0.97, RMSD 0.47 Å
- 4ZNX chain B against the predicted model P06241: TM-score 0.97, RMSD 0.47 Å
- 7A2Q chain A against the predicted model P06241: TM-score 0.97, RMSD 0.49 Å
- 4ZNX chain C against the predicted model P06241: TM-score 0.97, RMSD 0.48 Å
- 4ZNX chain C against the predicted model P06241: TM-score 0.97, RMSD 0.48 Å
- 4ZNX chain A against the predicted model P06241: TM-score 0.96, RMSD 0.53 Å
Elsewhere
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