Research workbench
Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine, glutamate, mk-801 and a GLUN2B-specific Fab, at pH 6.5
Analyse Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UOW
- Type
- protein
- Length
- 3,615 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- C0KD18, B7ZSK1, A7XY94
- Ligands
- BMK, NAG
Structure
electron microscopy · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 797 | — | C0KD18 |
| B | — | protein | 796 | — | B7ZSK1 |
| C | — | protein | 798 | — | C0KD18 |
| D | — | protein | 795 | — | A7XY94 |
| F | — | protein | 214 | — | — |
| G | — | protein | 215 | — | — |
Ligands and binding sites
- BMK · (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene · ligand · chains B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 16 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UOW · Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate… · the same entry in another collection · chain G against G, TM-score 1.00
- B7ZSK1 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (B7ZSK1) · a predicted model of the same protein · chain B against A, TM-score 0.94
- A7XY94 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2B (A7XY94) · a predicted model of the same protein · chain D against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0KD18
- Every structure of UniProt B7ZSK1
- Every structure of UniProt A7XY94
- Elsewhere: RCSB PDB 5UOW · PDBe 5UOW · UniProt C0KD18 · UniProt B7ZSK1 · UniProt A7XY94
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