UniProt A7XY94
Ionotropic glutamate receptor subunit NR2B (A7XY94)
Ionotropic glutamate receptor subunit NR2B (UniProt A7XY94): 26 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- A7XY94
- Protein
- Ionotropic glutamate receptor subunit NR2B
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 67 · 5 records with a druggable one
Structures
27 records of A7XY94 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4TLL | Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 | x-ray diffraction | B, D | — | — |
| 4TLL | Crystal structure of GLUN1/GLUN2B NMDA receptor, structure 1 | x-ray diffraction | B, D | — | — |
| 4TLM | Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 | x-ray diffraction | B, D | — | — |
| 4TLM | Crystal structure of GLUN1/GLUN2B NMDA receptor, structure 2 | x-ray diffraction | B, D | — | — |
| 5IOU | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation | electron microscopy | B, D | — | — |
| 5IOU | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the GLUTAMATE/GLYCINE-bound conformation | electron microscopy | B, D | — | — |
| 5IOV | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound… | electron microscopy | B, D | QEM | — |
| 5IOV | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the GLUTAMATE/GLYCINE/RO25-6981-bound… | electron microscopy | B, D | — | — |
| 5IPQ | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2 | electron microscopy | B, D | — | — |
| 5IPQ | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 2 | electron microscopy | B, D | — | — |
| 5IPR | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 3 | electron microscopy | B, D | — | — |
| 5IPR | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 3 | electron microscopy | B, D | — | — |
| 5IPS | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 4 | electron microscopy | B, D | — | — |
| 5IPS | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 4 | electron microscopy | B, D | — | — |
| 5IPT | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 5 | electron microscopy | B, D | — | 14 (best 0.76) |
| 5IPT | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 5 | electron microscopy | B, D | — | — |
| 5IPU | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 | electron microscopy | B, D | — | — |
| 5IPU | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 6 | electron microscopy | B, D | — | — |
| 5IPV | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 1 | electron microscopy | B, D | — | — |
| 5IPV | Cryo-EM structure of GLUN1/GLUN2B NMDA receptor in the DCKA/D-apv- bound conformation, state 1 | electron microscopy | B, D | — | — |
| 5UN1 | Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor | x-ray diffraction | B, H, F, D | NAG, BMK, GLU | 17 (best 0.86) |
| 5UN1 | Crystal structure of GLUN1/GLUN2B delta-atd NMDA receptor | x-ray diffraction | B, H, F, D | NAG, BMK | — |
| 5UOW | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a… | electron microscopy | D | NAG, BMK | 12 (best 0.90) |
| 5UOW | Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine, glutamate, mk-801 and a… | electron microscopy | D | NAG, BMK | — |
| 5UP2 | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981… | electron microscopy | D | NAG | 10 (best 0.89) |
| 5UP2 | Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine, glutamate, ro 25-6981… | electron microscopy | D | NAG | — |
| A7XY94 | AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2B (A7XY94) | predicted | A | — | 14 (best 0.73) |
Ligands
Experiment against prediction
- 5IOV chain D against the predicted model A7XY94: TM-score 0.93, RMSD 2.81 Å
- 5IOV chain D against the predicted model A7XY94: TM-score 0.93, RMSD 2.81 Å
- 5IOV chain B against the predicted model A7XY94: TM-score 0.92, RMSD 3.01 Å
- 5IOV chain B against the predicted model A7XY94: TM-score 0.92, RMSD 3.01 Å
- 5UP2 chain D against the predicted model A7XY94: TM-score 0.92, RMSD 3.00 Å
- 5UP2 chain D against the predicted model A7XY94: TM-score 0.92, RMSD 3.00 Å
- 5IOU chain B against the predicted model A7XY94: TM-score 0.92, RMSD 3.10 Å
- 5IOU chain B against the predicted model A7XY94: TM-score 0.92, RMSD 3.10 Å
- 4TLM chain D against the predicted model A7XY94: TM-score 0.91, RMSD 3.15 Å
- 4TLM chain D against the predicted model A7XY94: TM-score 0.91, RMSD 3.15 Å
Elsewhere
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