MolNFT v1 · #266289 · protein
AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (B7ZSK1)
B7ZSK1: “AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (B7ZSK1)”. 11 pockets (best druggability 0.72). MolNFT v1 #266289 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- B7ZSK1
- Type
- protein
- Length
- 1,451 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6Ee01E80b2Ce6582cc1bc5EE2465c8Eb47F96230
- Molecule
- Glutamate receptor ionotropic, NMDA 2A
- UniProt
- B7ZSK1
- Pockets
- 11 · best druggability 0.72
Structure
1 distinct chain · 25% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor ionotropic, NMDA 2A | protein | 1451 | 25% helix, 10% strand | B7ZSK1 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 700 | 0.72 | 0.79 | 67 | empty |
| 2 | 215 | 0.67 | 0.85 | 37 | empty |
| 3 | 382 | 0.58 | 0.75 | 48 | empty |
| 4 | 189 | 0.51 | 0.77 | 43 | empty |
| 5 | 141 | 0.49 | 0.79 | 28 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5UOW · Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine, glutamate… · an experimental structure of the same protein · chain A against B, TM-score 0.53
- 5UP2 · Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2B in complex with glycine, glutamate, ro… · an experimental structure of the same protein · chain A against B, TM-score 0.52
- 5UP2 · Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro… · an experimental structure of the same protein · chain A against B, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B7ZSK1
- Elsewhere: UniProt B7ZSK1 · AlphaFold DB B7ZSK1
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