Research workbench
Human origin recognition complex subunits 2 and 3
Analyse Human origin recognition complex subunits 2 and 3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UJ8
- Type
- protein
- Length
- 2,944 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Origin recognition complex subunit 3; Origin recognition complex subunit 2
- UniProt
- Q9UBD5, Q13416
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Origin recognition complex subunit 3 | protein | 553 | 62% helix, 5% strand | Q9UBD5 |
| E, F, G, H | Origin recognition complex subunit 2 | protein | 183 | 44% helix, 15% strand | Q13416 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 450 | 0.77 | 0.86 | 61 | empty |
| 2 | 95 | 0.77 | 0.97 | 22 | empty |
| 3 | 882 | 0.77 | 0.80 | 81 | empty |
| 4 | 373 | 0.77 | 0.86 | 55 | empty |
| 5 | 874 | 0.76 | 0.80 | 86 | empty |
Interfaces
9 interfaces between chains.
- C–H · 1710 Ų buried · 14 hydrogen bonds · protein-protein
- D–F · 1529 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 1427 Ų buried · 13 hydrogen bonds · protein-protein
- A–G · 1415 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1233 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 5UJ8 · Human Origin Recognition Complex subunits 2 and 3 · the same entry in another collection · chain H against H, TM-score 1.00
- Q13416 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 2 (Q13416) · a predicted model of the same protein · chain E against A, TM-score 0.93
- Q9UBD5 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 3 (Q9UBD5) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBD5
- Every structure of UniProt Q13416
- Elsewhere: RCSB PDB 5UJ8 · PDBe 5UJ8 · UniProt Q9UBD5 · UniProt Q13416
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