Research workbench
Crystal structure of KAP60 bound to yeast RCC1 (PRP20)
Analyse Crystal structure of KAP60 bound to yeast RCC1 (PRP20) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5T94
- Type
- protein
- Length
- 876 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide exchange factor SRM1; Importin subunit alpha
- UniProt
- P21827, Q02821
- Pockets
- 3 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide exchange factor SRM1 | protein | 454 | 7% helix, 39% strand | P21827 |
| B | Importin subunit alpha | protein | 422 | 73% helix, 0% strand | Q02821 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.84 | 0.86 | 82 | empty |
| 2 | 603 | 0.73 | 0.80 | 62 | empty |
| 3 | 202 | 0.47 | 0.75 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2012 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 5T94 · Crystal structure of Kap60 bound to yeast RCC1 (Prp20) · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P21827 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor SRM1 (P21827) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21827
- Every structure of UniProt Q02821
- Elsewhere: RCSB PDB 5T94 · PDBe 5T94 · UniProt P21827 · UniProt Q02821
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