MolNFT v1 · #335492 · protein
AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor SRM1 (P21827)
P21827: “AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor SRM1 (P21827)”. 2 pockets (best druggability 0.83). MolNFT v1 #335492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P21827
- Type
- protein
- Length
- 482 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xDAaB27434aDA8f5F5E5A6A9379845f7Dfb328c8b
- Molecule
- Guanine nucleotide exchange factor SRM1
- UniProt
- P21827
- Pockets
- 2 · best druggability 0.83
Structure
1 distinct chain · 10% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide exchange factor SRM1 | protein | 482 | 10% helix, 37% strand | P21827 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 468 | 0.83 | 0.90 | 58 | empty |
| 2 | 52 | 0.40 | 0.82 | 14 | empty |
Compared structures
- 5T94 · Crystal structure of Kap60 bound to yeast RCC1 (Prp20) · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 5T94 · Crystal structure of KAP60 bound to yeast RCC1 (PRP20) · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3OF7 · The crystal structure of PRP20P from saccharomyces cerevisiae and its binding properties… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3OF7 · The Crystal Structure of Prp20p from Saccharomyces cerevisiae and Its Binding Properties… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 5HQ2 · Structural model of SET8 histone H4 LYS20 methyltransferase bound to nucleosome core… · an experimental structure of the same protein · chain A against K, TM-score 0.85
- 5HQ2 · Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core… · an experimental structure of the same protein · chain A against K, TM-score 0.85
- 4OIH · Importin alpha in complex with the bipartite nls of PRP20 · an experimental structure of the same protein · chain A against B, TM-score 0.02
- 4OIH · Importin Alpha in Complex with the Bipartite NLS of Prp20 · an experimental structure of the same protein · chain A against B, TM-score 0.02
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21827
- Elsewhere: UniProt P21827 · AlphaFold DB P21827
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