Research workbench
Single chain recombinant globular head of the complement system protein C1Q
Analyse Single chain recombinant globular head of the complement system protein C1Q in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HKJ
- Type
- protein
- Length
- 402 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement C1Q subcomponent subunit A,COMPLEMENT C1Q subcomponent subunit C,COMPLEMENT…
- UniProt
- P02745, P02747, P02746
- Ligands
- NAG, CA
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement C1Q subcomponent subunit A,COMPLEMENT C1Q subcomponent subunit C,COMPLEMENT C1Q subcomponent subunit B | protein | 402 | 1% helix, 55% strand | P02745, P02747, P02746 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.63 | 0.83 | 26 | empty |
| 2 | 88 | 0.48 | 0.82 | 21 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5HKJ · Single Chain Recombinant Globular Head of the Complement System Protein C1q · the same entry in another collection · chain A against A, TM-score 1.00
- P02746 · AlphaFold monomer V2.0 prediction for complement C1Q subcomponent subunit B (P02746) · a predicted model of the same protein · chain A against A, TM-score 0.38
- P02747 · AlphaFold monomer V2.0 prediction for complement C1Q subcomponent subunit C (P02747) · a predicted model of the same protein · chain A against A, TM-score 0.34
- P02745 · AlphaFold monomer V2.0 prediction for complement C1Q subcomponent subunit a (P02745) · a predicted model of the same protein · chain A against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02745
- Every structure of UniProt P02747
- Every structure of UniProt P02746
- Elsewhere: RCSB PDB 5HKJ · PDBe 5HKJ · UniProt P02745 · UniProt P02747 · UniProt P02746
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