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Structural basis for the binding between tankyrase-1 and USP25

Analyse Structural basis for the binding between tankyrase-1 and USP25 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5GP7
Type: protein
Length: 173 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tankyrase-1; Ubiquitin carboxyl-terminal hydrolase 25
EC: 2.4.2.30
UniProt: O95271, Q9UHP3

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tankyrase-1 (EC 2.4.2.30)	protein	163	55% helix, 0% strand	O95271
B	Ubiquitin carboxyl-terminal hydrolase 25	protein	10	0% helix, 0% strand	Q9UHP3

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 655 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5GP7 · Structural basis for the binding between Tankyrase-1 and USP25 · the same entry in another collection · chain A against A, TM-score 1.00
Q9UHP3 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 25 (Q9UHP3) · a predicted model of the same protein · chain B against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95271
Every structure of UniProt Q9UHP3
Elsewhere: RCSB PDB 5GP7 · PDBe 5GP7 · UniProt O95271 · UniProt Q9UHP3

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