UniProt Q9UHP3
Ubiquitin carboxyl-terminal hydrolase 25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (UniProt Q9UHP3): 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UHP3
- Protein
- Ubiquitin carboxyl-terminal hydrolase 25
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 1 record with a druggable one
Structures
15 records of Q9UHP3 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MUX | SUMO2 non-covalently interacts with USP25 and downregulates its activity | solution nmr | A | — | — |
| 2MUX | SUMO2 non-covalently interacts with USP25 and downregulates its activity | solution nmr | A | — | — |
| 5GP7 | Structural basis for the binding between Tankyrase-1 and USP25 | x-ray diffraction | B | — | — |
| 5GP7 | Structural basis for the binding between tankyrase-1 and USP25 | x-ray diffraction | B | — | — |
| 5O71 | Crystal structure of human USP25 | x-ray diffraction | A | — | — |
| 5O71 | Crystal structure of human USP25 | x-ray diffraction | A | — | — |
| 6H4J | Usp25 catalytic domain | x-ray diffraction | A, B | CL | — |
| 6H4J | USP25 catalytic domain | x-ray diffraction | A, B | CL | — |
| 6H4K | Structure of the Usp25 C-terminal domain | x-ray diffraction | A | CL | — |
| 6H4K | Structure of the USP25 C-terminal domain | x-ray diffraction | A | CL | — |
| 6HEL | Structure of human USP25 | x-ray diffraction | A, B | — | — |
| 6HEL | Structure of human USP25 | x-ray diffraction | A, B | — | — |
| 6HEM | Structure of the C-terminal domain of USP25 (748-1048) | x-ray diffraction | A | NA | — |
| 6HEM | Structure of the C-terminal domain of USP25 (748-1048) | x-ray diffraction | A | NA | — |
| Q9UHP3 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 25 (Q9UHP3) | predicted | A | — | 12 (best 0.75) |
Ligands
Experiment against prediction
- 6HEL chain A against the predicted model Q9UHP3: TM-score 0.97, RMSD 1.41 Å
- 6HEL chain A against the predicted model Q9UHP3: TM-score 0.97, RMSD 1.41 Å
- 6HEL chain B against the predicted model Q9UHP3: TM-score 0.97, RMSD 1.43 Å
- 6HEL chain B against the predicted model Q9UHP3: TM-score 0.97, RMSD 1.43 Å
- 6HEM chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.36 Å
- 6HEM chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.36 Å
- 5O71 chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.59 Å
- 5O71 chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.59 Å
- 6H4K chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.44 Å
- 6H4K chain A against the predicted model Q9UHP3: TM-score 0.96, RMSD 1.44 Å
Elsewhere
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