UniProt O95271
Tankyrase-1 (O95271)
Tankyrase-1 (UniProt O95271), EC 2.4.2.30: 65 experimental structures on GenesisL1, 6 ligands bound, 14 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O95271
- Protein
- Tankyrase-1
- EC
- 2.4.2.30
- Experimental structures
- 65
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 14 · 1 record with a druggable one
Structures
65 records of O95271 in the MolNFT archive: 65 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RF5 | Crystal structure of human tankyrase 1- catalytic PARP domain | x-ray diffraction | A | — | — |
| 2RF5 | Crystal structure of human tankyrase 1- catalytic parp domain | x-ray diffraction | A | — | — |
| 3UDD | Tankyrase-1 in complex with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3UDD | Tankyrase-1 in complex with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3UH2 | Tankyrase-1 in complexed with PJ34 | x-ray diffraction | A, B | — | — |
| 3UH2 | Tankyrase-1 in complexed with PJ34 | x-ray diffraction | A, B | — | — |
| 3UH4 | TANKYRASE-1 complexed with NVP-XAV939 | x-ray diffraction | A, B | — | — |
| 3UH4 | Tankyrase-1 complexed with nvp-XAV939 | x-ray diffraction | A, B | — | — |
| 4DVI | Crystal structure of Tankyrase 1 with IWR2 | x-ray diffraction | A, B | — | — |
| 4DVI | Crystal structure of tankyrase 1 with IWR2 | x-ray diffraction | A, B | — | — |
| 4I9I | Crystal structure of tankyrase 1 with compound 4 | x-ray diffraction | A, B, C, D | — | — |
| 4I9I | Crystal structure of tankyrase 1 with compound 4 | x-ray diffraction | A, B, C, D | — | — |
| 4K4E | Co-crystal structure of tnks1 with compound 52 [N~2-(5-chloro-2-methoxyphenyl)-N-[trans-4-(2-oxo-2,3… | x-ray diffraction | A, B | — | — |
| 4K4E | Co-crystal structure of TNKS1 with compound 52 [N~2-(5-chloro-2… | x-ray diffraction | A, B | — | — |
| 4K4F | Co-crystal structure of TNKS1 with compound 18 [4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3… | x-ray diffraction | A, B | — | — |
| 4K4F | Co-crystal structure of TNKS1 with compound 18 [4-[(4S)-5,5-dimethyl… | x-ray diffraction | A, B | — | — |
| 4KRS | Tankyrase-1 complexed with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 4KRS | Tankyrase-1 complexed with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 4LI6 | TANKYRASE-1 Complexed with small molecule inhibitor… | x-ray diffraction | A, B | — | — |
| 4LI6 | Tankyrase-1 complexed with small molecule inhibitor N-[(4-oxo-3,4… | x-ray diffraction | A, B | — | — |
| 4LI7 | TANKYRASE-1 complexed with small molecule inhibitor… | x-ray diffraction | A, B | — | — |
| 4LI7 | Tankyrase-1 complexed with small molecule inhibitor 4-chloro-5-cyano… | x-ray diffraction | A, B | — | — |
| 4LI8 | TANKYRASE-1 complexed with small molecule inhibitor… | x-ray diffraction | A, B | — | — |
| 4LI8 | Tankyrase-1 complexed with small molecule inhibitor 2-[4-(4… | x-ray diffraction | A, B | — | — |
| 4MSG | Crystal structure of tankyrase 1 with compound 22 | x-ray diffraction | A, B | — | — |
| 4MSG | Crystal structure of tankyrase 1 with compound 22 | x-ray diffraction | A, B | — | — |
| 4MSK | Co-crystal structure of tankyrase 1 with compound 34 | x-ray diffraction | A, B, C, D | — | — |
| 4MSK | Co-crystal structure of tankyrase 1 with compound 34 | x-ray diffraction | A, B, C, D | — | — |
| 4MT9 | Co-crystal structure of tankyrase 1 with compound 49 | x-ray diffraction | A, B | — | — |
| 4MT9 | Co-crystal structure of tankyrase 1 with compound 49 | x-ray diffraction | A, B | — | — |
| 4N3R | Co-crystal structure of tankyrase 1 with compound 2… | x-ray diffraction | A, B | — | — |
| 4N3R | Co-crystal structure of tankyrase 1 with compound 2 (5-(2… | x-ray diffraction | A, B | — | — |
| 4N4V | Co-crystal structure of tankyrase 1 with compound 4… | x-ray diffraction | A, B | — | — |
| 4N4V | Co-crystal structure of tankyrase 1 with compound 4 [(4S)-3-{trans-4… | x-ray diffraction | A, B | — | — |
| 4OA7 | Crystal structure of Tankyrase1 in complex with IWR1 | x-ray diffraction | A, B, C, D | — | — |
| 4OA7 | Crystal structure of TANKYRASE1 in complex with IWR1 | x-ray diffraction | A, B, C, D | — | — |
| 4TOR | Crystal structure of Tankyrase 1 with IWR-8 | x-ray diffraction | A, B, C, D | — | — |
| 4TOR | Crystal structure of tankyrase 1 with iwr-8 | x-ray diffraction | A, B, C, D | — | — |
| 4TOS | Crystal structure of Tankyrase 1 with 355 | x-ray diffraction | A, B | — | — |
| 4TOS | Crystal structure of tankyrase 1 with 355 | x-ray diffraction | A, B | — | — |
| 4U6A | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 4U6A | X-ray crystal structure of human tnks in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 4UUH | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 4UUH | X-ray crystal structure of human tnks in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 4UW1 | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4UW1 | X-ray crystal structure of human tnks in complex with a small molecule inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4W5S | Tankyrase in complex with compound | x-ray diffraction | A | — | — |
| 4W5S | Tankyrase in complex with compound | x-ray diffraction | A | — | — |
| 4W6E | Human Tankyrase 1 with small molecule inhibitor | x-ray diffraction | A | — | — |
| 4W6E | Human tankyrase 1 with small molecule inhibitor | x-ray diffraction | A | — | — |
| 5EBT | Tankyrase 1 with Phthalazi 2 | x-ray diffraction | A, B, C, D | 5N8, ZN | — |
| 5EBT | Tankyrase 1 with phthalazinone 2 | x-ray diffraction | A, B, C, D | — | — |
| 5ECE | Tankyrase 1 with Phthalazi 1 | x-ray diffraction | A, B, C, D | 5N2, ZN | — |
| 5ECE | Tankyrase 1 with phthalazinone 1 | x-ray diffraction | A, B, C, D | — | — |
| 5ETY | Crystal Structure of human Tankyrase-1 bound to K-756 | x-ray diffraction | A, B, C, D | ZN, K56 | — |
| 5ETY | Crystal structure of human tankyrase-1 bound to K-756 | x-ray diffraction | A, B, C, D | — | — |
| 5GP7 | Structural basis for the binding between tankyrase-1 and USP25 | x-ray diffraction | A | — | — |
| 5JHQ | ARCs 1-3 of human Tankyrase-1 bound to a peptide derived from IRAP | x-ray diffraction | A, B, C, D | — | 14 (best 0.72) |
| 5JHQ | Arcs 1-3 of human tankyrase-1 bound to a peptide derived from irap | x-ray diffraction | A, B, C, D | — | — |
| 5JTI | Crystal structure of the human tankyrase 1 (tnks) SAM domain (D1055R), crystal form 2 | x-ray diffraction | A, B, C, D, E, F | — | — |
5 records more on the page itself.
Ligands
- ZN · Zinc ion · in 4 records
- 5N2 · 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile · in 1 record
- 5N8 · 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one · in 1 record
- JKN · 6,8-bis(fluoranyl)-2-[4-(2-oxidanylpropan-2-yl)phenyl]-3~{H}-quinazolin-4-one · in 1 record
- K56 · 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one · in 1 record
- SO4 · Sulfate ion · in 1 record
Elsewhere
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