Research workbench
Crystal structure of the P-REX1 DH/PH tandem in complex with CDC42
Analyse Crystal structure of the P-REX1 DH/PH tandem in complex with CDC42 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FI1
- Type
- protein
- Length
- 524 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1…
- UniProt
- Q8TCU6, P60953
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 PROTEIN,PHOSPHATIDYLINOSITOL 3,4,5-trisphosphate- dependent rac exchanger 1 protein | protein | 344 | 60% helix, 16% strand | Q8TCU6 |
| B | Cell division control protein 42 homolog | protein | 180 | 36% helix, 23% strand | P60953 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.68 | 0.77 | 66 | empty |
| 2 | 263 | 0.62 | 0.80 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1446 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5FI1 · Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TCU6 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate-dependent… · a predicted model of the same protein · chain A against A, TM-score 0.97
- P60953 · AlphaFold monomer V2.0 prediction for cell division control protein 42 homolog (P60953) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TCU6
- Every structure of UniProt P60953
- Elsewhere: RCSB PDB 5FI1 · PDBe 5FI1 · UniProt Q8TCU6 · UniProt P60953
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