UniProt Q8TCU6
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Q8TCU6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (UniProt Q8TCU6), EC 3.2.1.17: 23 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 47 pockets. Binding sites, druggability and…
- UniProt
- Q8TCU6
- Protein
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
- EC
- 3.2.1.17
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 47 · 3 records with a druggable one
Structures
24 records of Q8TCU6 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QIK | Crystal structure of the first PDZ domain of PREX1 | x-ray diffraction | A | — | — |
| 3QIK | Crystal structure of the first PDZ domain of PREX1 | x-ray diffraction | A | — | — |
| 4YON | P-Rex1:Rac1 complex | x-ray diffraction | A | — | — |
| 4YON | P-REX1:RAC1 complex | x-ray diffraction | A | — | — |
| 5D27 | Crystal Structure of the P-Rex1 PH domain | x-ray diffraction | A | NI | — |
| 5D27 | Crystal structure of the P-REX1 pH domain | x-ray diffraction | A | — | — |
| 5D3V | Crystal Structure of the P-Rex1 PH domain with Citrate Bound | x-ray diffraction | A, B | — | — |
| 5D3V | Crystal structure of the P-REX1 pH domain with citrate bound | x-ray diffraction | A, B | — | — |
| 5D3W | Crystal structure of the P-REX1 pH domain with sulfate bound | x-ray diffraction | A, B | — | — |
| 5D3X | Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound | x-ray diffraction | A, B | 4IP | 1 (best 0.47) |
| 5D3X | Crystal structure of the P-REX1 pH domain with inositol-(1,3,4,5)- tetrakisphosphate bound | x-ray diffraction | A, B | — | — |
| 5D3Y | Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound | x-ray diffraction | A, B | 4IP | 1 (best 0.39) |
| 5D3Y | Crystal structure of the P-REX1 pH domain with inositol-(1,3,4,5)- tetrakisphosphate bound | x-ray diffraction | A, B | — | — |
| 5FI0 | Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 | x-ray diffraction | A, C, E, G | PO4 | — |
| 5FI0 | Crystal structure of the P-REX1 DH/PH tandem in complex with RAC1 | x-ray diffraction | A, C, E, G | — | — |
| 5FI1 | Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 | x-ray diffraction | A | — | — |
| 5FI1 | Crystal structure of the P-REX1 DH/PH tandem in complex with CDC42 | x-ray diffraction | A | — | — |
| 6VSK | Crystal structure of the P-Rex1 DEP1 domain | x-ray diffraction | A | — | 1 (best 0.27) |
| 6VSK | Crystal structure of the P-REX1 DEP1 domain | x-ray diffraction | A | — | — |
| 7RX9 | Structure of autoinhibited P-Rex1 | x-ray diffraction | A | SO4 | 4 (best 0.60) |
| 7RX9 | Structure of autoinhibited P-REX1 | x-ray diffraction | A | SO4 | — |
| 7SYF | Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | electron microscopy | A | — | 20 (best 0.82) |
| 7SYF | Reconstruction of full-length prex-1 (PTDINS(3,4,5)P3-dependent rac exchanger 1) | electron microscopy | A | — | — |
| Q8TCU6 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate-dependent rac… | predicted | A | — | 20 (best 0.82) |
Ligands
Experiment against prediction
- 5FI1 chain A against the predicted model Q8TCU6: TM-score 0.97, RMSD 1.16 Å
- 5FI1 chain A against the predicted model Q8TCU6: TM-score 0.97, RMSD 1.16 Å
- 5D3Y chain A against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.98 Å
- 5D3Y chain A against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.98 Å
- 5D3Y chain B against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.97 Å
- 5D3V chain B against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.82 Å
- 5D3V chain B against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.82 Å
- 5D3W chain B against the predicted model Q8TCU6: TM-score 0.97, RMSD 0.99 Å
- 5D3X chain A against the predicted model Q8TCU6: TM-score 0.96, RMSD 1.04 Å
- 5D3X chain A against the predicted model Q8TCU6: TM-score 0.96, RMSD 1.04 Å
Elsewhere
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