MolNFT v1 · #308398 · protein
AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein (Q8TCU6)
Q8TCU6: “AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1…”. 20 pockets (best druggability 0.82). MolNFT v1 #308398 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8TCU6
- Type
- protein
- Length
- 1,659 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x844c0a881E7457F55a632E14DcEd1163DE274C59
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein
- UniProt
- Q8TCU6
- Pockets
- 20 · best druggability 0.82
Structure
1 distinct chain · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein | protein | 1659 | 45% helix, 16% strand | Q8TCU6 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.82 | 0.91 | 74 | empty |
| 2 | 590 | 0.74 | 0.81 | 52 | empty |
| 3 | 341 | 0.72 | 0.84 | 31 | empty |
| 4 | 76 | 0.70 | 0.95 | 19 | empty |
| 5 | 346 | 0.70 | 0.83 | 35 | empty |
Compared structures
- 7SYF · Reconstruction of full-length prex-1 (PTDINS(3,4,5)P3-dependent rac exchanger 1) · an experimental structure of the same protein · chain A against A, TM-score 0.59
- 5FI1 · Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 5FI1 · Crystal structure of the P-REX1 DH/PH tandem in complex with CDC42 · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 5FI0 · Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 · an experimental structure of the same protein · chain A against E, TM-score 0.20
- 5FI0 · Crystal structure of the P-REX1 DH/PH tandem in complex with RAC1 · an experimental structure of the same protein · chain A against E, TM-score 0.20
- 4YON · P-Rex1:Rac1 complex · an experimental structure of the same protein · chain A against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TCU6
- Elsewhere: UniProt Q8TCU6 · AlphaFold DB Q8TCU6
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