MolNFT v1 · #187833 · protein

Reconstruction of full-length prex-1 (PTDINS(3,4,5)P3-dependent rac exchanger 1)

7SYF · Phosphatidylinositol 3,4,5-trisphosphate-dependent rac…: “Reconstruction of full-length prex-1 (PTDINS(3,4,5)P3-dependent rac exchanger 1)”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #187833 on GenesisL1…

PDB: 7SYF
Type: protein
Length: 1,391 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 PROTEIN,ENDOLYSIN…
EC: 3.2.1.17
UniProt: Q8TCU6
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 52% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 PROTEIN,ENDOLYSIN chimera (EC 3.2.1.17)	protein	1391	52% helix, 17% strand	Q8TCU6

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.82	0.96	49	empty
2	67	0.71	0.97	29	empty
3	60	0.70	0.97	19	empty
4	388	0.67	0.80	49	empty
5	635	0.65	0.75	67	empty

Compared structures

7SYF · Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) · the same entry in another collection · chain A against A, TM-score 1.00
Q8TCU6 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate-dependent… · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TCU6
Elsewhere: RCSB PDB 7SYF · PDBe 7SYF · UniProt Q8TCU6

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