Research workbench

MGLUR3 with glutamate

Analyse MGLUR3 with glutamate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CNK
Type: protein
Length: 1,330 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 3
UniProt: Q14832
Ligands: GGL, IOD
Pockets: 13 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 36% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metabotropic glutamate receptor 3	protein	444	36% helix, 20% strand	Q14832
B	Metabotropic glutamate receptor 3	protein	438	36% helix, 19% strand	Q14832
C	Metabotropic glutamate receptor 3	protein	448	35% helix, 20% strand	Q14832

Ligands and binding sites

GGL · Gamma-L-glutamic acid · ligand · chains A
IOD · Iodide ion · ion · 10 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	686	0.73	0.80	83	IOD
2	79	0.72	0.97	23	GGL, IOD
3	781	0.72	0.78	81	IOD
4	698	0.71	0.78	80	IOD
5	519	0.70	0.80	61	empty

Interfaces

3 interfaces between chains.

A–B · 511 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 338 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 335 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

5CNK · mglur3 with glutamate · the same entry in another collection · chain A against A, TM-score 1.00
Q14832 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 3 (Q14832) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14832
Elsewhere: RCSB PDB 5CNK · PDBe 5CNK · UniProt Q14832

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