Research workbench
Apo CTPRC2 in an autoinhibited state
Analyse Apo CTPRC2 in an autoinhibited state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5BJS
- Type
- protein
- Length
- 1,265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycomb protein eed; Histone-lysine N-methyltransferase EZH2, polycomb protein SUZ12
- UniProt
- G0S8H7, G0SDW4, G0RYC6
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polycomb protein eed | protein | 464 | 8% helix, 41% strand | G0S8H7 |
| B | Histone-lysine N-methyltransferase EZH2, polycomb protein SUZ12 | protein | 801 | 36% helix, 12% strand | G0SDW4, G0RYC6 |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 770 | 0.86 | 0.89 | 66 | empty |
| 2 | 883 | 0.84 | 0.86 | 108 | empty |
| 3 | 432 | 0.80 | 0.88 | 58 | empty |
| 4 | 347 | 0.73 | 0.85 | 55 | empty |
| 5 | 388 | 0.68 | 0.81 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 5379 Ų buried · 73 hydrogen bonds · protein-protein
Compared structures
- 5BJS · Apo ctPRC2 in an autoinhibited state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S8H7
- Every structure of UniProt G0SDW4
- Every structure of UniProt G0RYC6
- Elsewhere: RCSB PDB 5BJS · PDBe 5BJS · UniProt G0S8H7 · UniProt G0SDW4 · UniProt G0RYC6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.