UniProt G0RYC6
Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera (G0RYC6)
Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera (UniProt G0RYC6): 18 experimental structures on GenesisL1, 5 ligands bound, 123 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- G0RYC6
- Protein
- Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 123 · 8 records with a druggable one
Structures
18 records of G0RYC6 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5BJS | Apo ctPRC2 in an autoinhibited state | x-ray diffraction | B | ZN | 18 (best 0.86) |
| 5BJS | Apo CTPRC2 in an autoinhibited state | x-ray diffraction | B | — | — |
| 5KJH | Crystal structure of an active polycomb repressive complex 2 in the stimulated state | x-ray diffraction | B | ZN, SAH | 14 (best 0.86) |
| 5KJH | Crystal structure of an active polycomb repressive complex 2 in the stimulated state | x-ray diffraction | B | ZN | — |
| 5KJI | Crystal structure of an active polycomb repressive complex 2 in the basal state | x-ray diffraction | B | ZN, SAH | 12 (best 0.86) |
| 5KJI | Crystal structure of an active polycomb repressive complex 2 in the basal state | x-ray diffraction | B | ZN | — |
| 5KKL | Structure of ctPRC2 in complex with H3K27me3 and H3K27M | x-ray diffraction | B | ZN, SAM | 18 (best 0.87) |
| 5KKL | Structure of CTPRC2 in complex with H3K27ME3 and H3K27M | x-ray diffraction | B | ZN | — |
| 5TQR | ctPRC2 in an autoinhibited conformation bound to S-adenosylmethionine | x-ray diffraction | B | ZN, SAM | 18 (best 0.86) |
| 5TQR | CTPRC2 in an autoinhibited conformation bound to S-adenosylmethionine | x-ray diffraction | B | ZN | — |
| 5VK3 | Apo ctPRC2 with E840A and K852D mutations in Ezh2 | x-ray diffraction | B | ZN | — |
| 5VK3 | Apo CTPRC2 with E840A and K852D mutations in EZH2 | x-ray diffraction | B | ZN | — |
| 5WF7 | Chaetomium thermophilum Polycomb Repressive Complex 2 bound to GSK126 | x-ray diffraction | B | ZN, A9G | — |
| 5WF7 | Chaetomium thermophilum polycomb repressive complex 2 bound to GSK126 | x-ray diffraction | B | ZN, A9G | 14 (best 0.85) |
| 5WFC | Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the… | x-ray diffraction | B | ZN, A97 | 14 (best 0.85) |
| 5WFC | Humanized mutant of the chaetomium thermophilum polycomb repressive complex 2 bound to the… | x-ray diffraction | B | ZN, A97 | — |
| 5WFD | Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the… | x-ray diffraction | B | ZN, A9G | 15 (best 0.85) |
| 5WFD | Humanized mutant of the chaetomium thermophilum polycomb repressive complex 2 bound to the… | x-ray diffraction | B | ZN, A9G | — |
Ligands
- ZN · Zinc ion · in 17 records
- A9G · 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide · in 4 records
- A97 · N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl) methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide · in 2 records
- SAH · S-adenosyl-L-homocysteine · in 2 records
- SAM · S-adenosylmethionine · in 2 records
Experiment against prediction
- 5KKL chain B against the predicted model P68431: TM-score 0.08, RMSD 4.88 Å
Elsewhere
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