UniProt G0SDW4
Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12 (G0SDW4)
Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12 (UniProt G0SDW4): 17 experimental structures on GenesisL1, 5 ligands bound, 97 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- G0SDW4
- Protein
- Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 97 · 6 records with a druggable one
Structures
17 records of G0SDW4 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5BJS | Apo ctPRC2 in an autoinhibited state | x-ray diffraction | B | ZN | 18 (best 0.86) |
| 5BJS | Apo CTPRC2 in an autoinhibited state | x-ray diffraction | B | — | — |
| 5KJH | Crystal structure of an active polycomb repressive complex 2 in the stimulated state | x-ray diffraction | B | ZN, SAH | 14 (best 0.86) |
| 5KJH | Crystal structure of an active polycomb repressive complex 2 in the stimulated state | x-ray diffraction | B | ZN | — |
| 5KJI | Crystal structure of an active polycomb repressive complex 2 in the basal state | x-ray diffraction | B | ZN, SAH | 12 (best 0.86) |
| 5KJI | Crystal structure of an active polycomb repressive complex 2 in the basal state | x-ray diffraction | B | ZN | — |
| 5KKL | Structure of ctPRC2 in complex with H3K27me3 and H3K27M | x-ray diffraction | B | ZN, SAM | 18 (best 0.87) |
| 5KKL | Structure of CTPRC2 in complex with H3K27ME3 and H3K27M | x-ray diffraction | B | ZN | — |
| 5M5G | Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2) | x-ray diffraction | B | ZN, SAH | 17 (best 0.86) |
| 5M5G | Crystal structure of the chaetomium thermophilum polycomb repressive complex 2 (PRC2) | x-ray diffraction | B | ZN | — |
| 5TQR | ctPRC2 in an autoinhibited conformation bound to S-adenosylmethionine | x-ray diffraction | B | ZN, SAM | 18 (best 0.86) |
| 5TQR | CTPRC2 in an autoinhibited conformation bound to S-adenosylmethionine | x-ray diffraction | B | ZN | — |
| 5VK3 | Apo ctPRC2 with E840A and K852D mutations in Ezh2 | x-ray diffraction | B | ZN | — |
| 5VK3 | Apo CTPRC2 with E840A and K852D mutations in EZH2 | x-ray diffraction | B | ZN | — |
| 5WF7 | Chaetomium thermophilum Polycomb Repressive Complex 2 bound to GSK126 | x-ray diffraction | B | ZN, A9G | — |
| 5WFC | Humanized mutant of the chaetomium thermophilum polycomb repressive complex 2 bound to the… | x-ray diffraction | B | ZN, A97 | — |
| 5WFD | Humanized mutant of the chaetomium thermophilum polycomb repressive complex 2 bound to the… | x-ray diffraction | B | ZN, A9G | — |
Ligands
- ZN · Zinc ion · in 16 records
- SAH · S-adenosyl-L-homocysteine · in 3 records
- A9G · 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide · in 2 records
- SAM · S-adenosylmethionine · in 2 records
- A97 · N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl) methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide · in 1 record
Experiment against prediction
- 5KKL chain B against the predicted model P68431: TM-score 0.08, RMSD 4.88 Å
Elsewhere
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