Research workbench
Human nucleosome core particle
Analyse Human nucleosome core particle in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AV5
- Type
- protein + DNA
- Length
- 1,063 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3.1; Histone H4; Histone H2A type 1-B/E; Histone H2B type 1-J; DNA (147-mer)
- UniProt
- P68431, P62805, P04908, P06899
- Ligands
- MN
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 9 distinct chains · 63% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Histone H3.1 | protein | 99 | 63% helix, 4% strand | P68431 |
| B | Histone H4 | protein | 82 | 60% helix, 9% strand | P62805 |
| C | Histone H2A type 1-B/E | protein | 106 | 57% helix, 7% strand | P04908 |
| D | Histone H2B type 1-J | protein | 97 | 71% helix, 4% strand | P06899 |
| F | Histone H4 | protein | 87 | 57% helix, 8% strand | P62805 |
| G | Histone H2A type 1-B/E | protein | 105 | 56% helix, 7% strand | P04908 |
| H | Histone H2B type 1-J | protein | 94 | 74% helix, 4% strand | P06899 |
| I | DNA (147-mer) | dna | 147 | — | — |
| J | DNA (147-mer) | dna | 147 | — | — |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 14 copies · chains E, F, I, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.78 | 0.83 | 69 | empty |
| 2 | 527 | 0.77 | 0.84 | 61 | empty |
| 3 | 515 | 0.76 | 0.84 | 56 | empty |
| 4 | 1130 | 0.72 | 0.76 | 87 | empty |
| 5 | 774 | 0.70 | 0.77 | 51 | empty |
Interfaces
36 interfaces between chains.
- I–J · 6494 Ų buried · 617 hydrogen bonds · nucleic-nucleic
- E–F · 2645 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 2629 Ų buried · 24 hydrogen bonds · protein-protein
- G–H · 2614 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2569 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 5AV5 · human nucleosome core particle · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68431
- Every structure of UniProt P62805
- Every structure of UniProt P04908
- Every structure of UniProt P06899
- Elsewhere: RCSB PDB 5AV5 · PDBe 5AV5 · UniProt P68431 · UniProt P62805 · UniProt P04908 · UniProt P06899
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