Research workbench
Structural analysis of mouse GSK3BETA fused with LRP6 peptide.
Analyse Structural analysis of mouse GSK3BETA fused with LRP6 peptide. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AIR
- Type
- protein
- Length
- 714 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Low-density lipoprotein receptor-related protein 6,GLYCOGEN synthase kinase-3 beta
- EC
- 2.7.11.26, 2.7.11.1
- UniProt
- O75581, Q9WV60
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Low-density lipoprotein receptor-related protein 6,GLYCOGEN synthase kinase-3 beta (EC 2.7.11.26, 2.7.11.1) | protein | 353 | 36% helix, 20% strand | O75581, Q9WV60 |
| B | Low-density lipoprotein receptor-related protein 6,GLYCOGEN synthase kinase-3 beta (EC 2.7.11.26, 2.7.11.1) | protein | 361 | 35% helix, 19% strand | O75581, Q9WV60 |
Ligands and binding sites
- MLI · Malonate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1110 | 0.78 | 0.80 | 85 | MLI |
| 2 | 102 | 0.75 | 0.97 | 32 | empty |
| 3 | 462 | 0.71 | 0.81 | 45 | MLI |
| 4 | 409 | 0.67 | 0.80 | 41 | empty |
| 5 | 90 | 0.55 | 0.85 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1415 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5AIR · Structural analysis of mouse GSK3beta fused with LRP6 peptide. · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WV60 · AlphaFold monomer V2.0 prediction for glycogen synthase kinase-3 beta (Q9WV60) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O75581 · AlphaFold monomer V2.0 prediction for low-density lipoprotein receptor-related protein 6… · a predicted model of the same protein · chain B against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75581
- Every structure of UniProt Q9WV60
- Elsewhere: RCSB PDB 5AIR · PDBe 5AIR · UniProt O75581 · UniProt Q9WV60
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