UniProt Q9WV60
Glycogen synthase kinase-3 beta (Q9WV60)
Glycogen synthase kinase-3 beta (UniProt Q9WV60), EC 2.7.11.1, 2.7.11.26: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9WV60
- Protein
- Glycogen synthase kinase-3 beta
- EC
- 2.7.11.1, 2.7.11.26
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 4 · 1 record with a druggable one
Structures
7 records of Q9WV60 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NU1 | Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated… | x-ray diffraction | A | — | — |
| 4NU1 | Crystal structure of a transition state mimic of the gsk-3/AXIN complex bound to phosphorylated… | x-ray diffraction | A | — | — |
| 5AIR | Structural analysis of mouse GSK3beta fused with LRP6 peptide. | x-ray diffraction | A, B | — | — |
| 5AIR | Structural analysis of mouse GSK3BETA fused with LRP6 peptide. | x-ray diffraction | A, B | — | — |
| 6AE3 | Crystal structure of GSK3BETA complexed with morin | x-ray diffraction | A, B, C, D | MRI | — |
| 8VMF | Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin… | x-ray diffraction | A | MG, AF3, ADP, CL | 4 (best 0.74) |
| Q9WV60 | AlphaFold monomer V2.0 prediction for glycogen synthase kinase-3 beta (Q9WV60) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6AE3 chain C against the predicted model Q9WV60: TM-score 0.99, RMSD 0.72 Å
- 6AE3 chain D against the predicted model Q9WV60: TM-score 0.99, RMSD 0.82 Å
- 6AE3 chain B against the predicted model Q9WV60: TM-score 0.99, RMSD 0.84 Å
- 5AIR chain A against the predicted model Q9WV60: TM-score 0.99, RMSD 0.87 Å
- 5AIR chain A against the predicted model Q9WV60: TM-score 0.99, RMSD 0.87 Å
- 6AE3 chain A against the predicted model Q9WV60: TM-score 0.98, RMSD 0.99 Å
- 4NU1 chain A against the predicted model Q9WV60: TM-score 0.98, RMSD 1.09 Å
- 4NU1 chain A against the predicted model Q9WV60: TM-score 0.98, RMSD 1.09 Å
- 5AIR chain B against the predicted model Q9WV60: TM-score 0.98, RMSD 1.02 Å
- 5AIR chain B against the predicted model Q9WV60: TM-score 0.98, RMSD 1.02 Å
Elsewhere
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