Research workbench
P-REX1:RAC1 complex
Analyse P-REX1:RAC1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YON
- Type
- protein
- Length
- 525 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein; RAS-related…
- UniProt
- Q8TCU6, P63000
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein | protein | 349 | 60% helix, 15% strand | Q8TCU6 |
| B | RAS-related C3 botulinum toxin substrate 1 | protein | 176 | 38% helix, 23% strand | P63000 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.60 | 0.85 | 21 | empty |
| 2 | 306 | 0.60 | 0.78 | 31 | empty |
| 3 | 287 | 0.57 | 0.77 | 34 | empty |
| 4 | 79 | 0.32 | 0.74 | 16 | empty |
| 5 | 52 | 0.29 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1370 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TCU6
- Every structure of UniProt P63000
- Elsewhere: RCSB PDB 4YON · PDBe 4YON · UniProt Q8TCU6 · UniProt P63000
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.