UniProt P63000
Ras-related C3 botulinum toxin substrate 1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (UniProt P63000), EC 3.6.5.2: 93 experimental structures on GenesisL1, 16 ligands bound, 23 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P63000
- Protein
- Ras-related C3 botulinum toxin substrate 1
- EC
- 3.6.5.2
- Experimental structures
- 93
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 23 · 5 records with a druggable one
Structures
93 records of P63000 in the MolNFT archive: 93 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FOE | Crystal structure of RAC1 in complex with the guanine nucleotide exchange region of TIAM1 | x-ray diffraction | B, D, F, H | — | — |
| 1FOE | Crystal structure of RAC1 in complex with the guanine nucleotide exchange region of TIAM1 | x-ray diffraction | B, D, F, H | — | — |
| 1G4U | Crystal structure of the salmonella tyrosine phosphatase and GTPase activating protein sptp bound… | x-ray diffraction | R | — | — |
| 1G4U | Crystal structure of the salmonella tyrosine phosphatase and GTPase activating protein sptp bound… | x-ray diffraction | R | — | — |
| 1I4D | Crystal structure analysis of RAC1-GDP complexed with arfaptin (P21) | x-ray diffraction | D | — | — |
| 1I4D | Crystal structure analysis of RAC1-GDP complexed with arfaptin (P21) | x-ray diffraction | D | — | — |
| 1I4L | Crystal structure analysis of RAC1-GDP in complex with arfaptin (P41) | x-ray diffraction | D | — | — |
| 1I4L | Crystal structure analysis of RAC1-GDP in complex with arfaptin (P41) | x-ray diffraction | D | — | — |
| 1I4T | Crystal structure analysis of RAC1-gmppnp in complex with arfaptin | x-ray diffraction | D | — | — |
| 1I4T | Crystal structure analysis of RAC1-gmppnp in complex with arfaptin | x-ray diffraction | D | — | — |
| 1MH1 | Small G-protein | x-ray diffraction | A | — | — |
| 1MH1 | Small G-protein | x-ray diffraction | A | — | — |
| 1RYF | Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase | x-ray diffraction | A, B | — | — |
| 1RYF | Alternative splicing of RAC1 generates RAC1B, a self-activating GTPase | x-ray diffraction | A, B | — | — |
| 1RYH | Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase | x-ray diffraction | A, B | — | — |
| 1RYH | Alternative splicing of RAC1 generates RAC1B, a self-activating GTPase | x-ray diffraction | A, B | — | — |
| 2FJU | Activated Rac1 bound to its effector phospholipase C beta 2 | x-ray diffraction | A | — | — |
| 2FJU | Activated RAC1 bound to its effector phospholipase C beta 2 | x-ray diffraction | A | — | — |
| 2H7V | Co-crystal structure of YpkA-Rac1 | x-ray diffraction | A, B | — | — |
| 2H7V | Co-crystal structure of ypka-RAC1 | x-ray diffraction | A, B | — | — |
| 2NZ8 | N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | x-ray diffraction | A | — | — |
| 2NZ8 | N-terminal dhph cassette of trio in complex with nucleotide-free RAC1 | x-ray diffraction | A | — | — |
| 2P2L | Rac1-GDP-Zinc Complex | x-ray diffraction | A, B, C | — | — |
| 2P2L | RAC1-GDP-zinc complex | x-ray diffraction | A, B, C | — | — |
| 2RMK | Rac1/PRK1 Complex | solution nmr | A | — | — |
| 2RMK | RAC1/PRK1 complex | solution nmr | A | — | — |
| 2VRW | Critical structural role for the PH and C1 domains of the Vav1 exchange factor | x-ray diffraction | A | — | — |
| 2VRW | Critical structural role for the pH and C1 domains of the VAV1 exchange factor | x-ray diffraction | A | — | — |
| 2WKP | Structure of a photoactivatable Rac1 containing Lov2 Wildtype | x-ray diffraction | A | — | — |
| 2WKP | Structure of a photoactivatable RAC1 containing LOV2 wildtype | x-ray diffraction | A | — | — |
| 2WKQ | Structure of a photoactivatable Rac1 containing the Lov2 C450A Mutant | x-ray diffraction | A | — | — |
| 2WKQ | Structure of a photoactivatable RAC1 containing the LOV2 C450A mutant | x-ray diffraction | A | — | — |
| 2WKR | Structure of a photoactivatable Rac1 containing the Lov2 C450M Mutant | x-ray diffraction | A | — | — |
| 2WKR | Structure of a photoactivatable RAC1 containing the LOV2 C450M mutant | x-ray diffraction | A | — | — |
| 2YIN | STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. | x-ray diffraction | C, D | — | — |
| 2YIN | Structure of the complex between DOCK2 and RAC1. | x-ray diffraction | C, D | — | — |
| 3B13 | Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant) | x-ray diffraction | B, D | — | — |
| 3B13 | Crystal structure of the dhr-2 domain of DOCK2 in complex with RAC1 (T17N mutant) | x-ray diffraction | B, D | — | — |
| 3BJI | Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 | x-ray diffraction | C, D | — | — |
| 3BJI | Structural basis of promiscuous guanine nucleotide exchange by the T-cell essential VAV1 | x-ray diffraction | C, D | — | — |
| 3RYT | The Plexin A1 intracellular region in complex with Rac1 | x-ray diffraction | C | — | — |
| 3RYT | The plexin A1 intracellular region in complex with RAC1 | x-ray diffraction | C | — | — |
| 3SBD | Crystal structure of RAC1 P29S mutant | x-ray diffraction | A, B | — | — |
| 3SBD | Crystal structure of RAC1 P29S mutant | x-ray diffraction | A, B | — | — |
| 3SBE | Crystal structure of RAC1 P29S mutant | x-ray diffraction | A | — | — |
| 3SBE | Crystal structure of RAC1 P29S mutant | x-ray diffraction | A | — | — |
| 3SU8 | Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1 | x-ray diffraction | A | — | — |
| 3SU8 | Crystal structure of a truncated intracellular domain of plexin-B1 in complex with RAC1 | x-ray diffraction | A | — | — |
| 3SUA | Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 | x-ray diffraction | A, B, C | — | — |
| 3SUA | Crystal structure of the intracellular domain of plexin-B1 in complex with RAC1 | x-ray diffraction | A, B, C | — | — |
| 3TH5 | Crystal structure of wild-type RAC1 | x-ray diffraction | A, B | — | — |
| 3TH5 | Crystal structure of wild-type RAC1 | x-ray diffraction | A, B | — | — |
| 4GZL | Crystal structure of RAC1 Q61L mutant | x-ray diffraction | A, B | — | — |
| 4GZL | Crystal structure of RAC1 Q61L mutant | x-ray diffraction | A, B | — | — |
| 4GZM | Crystal structure of RAC1 F28L mutant | x-ray diffraction | A, B | — | — |
| 4GZM | Crystal structure of RAC1 F28L mutant | x-ray diffraction | A, B | — | — |
| 4YON | P-Rex1:Rac1 complex | x-ray diffraction | B | — | — |
| 4YON | P-REX1:RAC1 complex | x-ray diffraction | B | — | — |
| 5FI0 | Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 | x-ray diffraction | B, D, F, H | — | — |
| 5FI0 | Crystal structure of the P-REX1 DH/PH tandem in complex with RAC1 | x-ray diffraction | B, D, F, H | — | — |
33 records more on the page itself.
Ligands
- GDP · Guanosine-5'-diphosphate · in 4 records
- MG · Magnesium ion · in 4 records
- GTP · Guanosine-5'-triphosphate · in 2 records
- JGA · N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea · in 2 records
- N5S · N-(5-methyl-1,2-oxazol-3-yl)-N'-[(3S)-4,4,4-trifluoro-3-hydroxy-3-(5-methylfuran-2-yl)butyl]urea · in 2 records
- N5V · N-ethyl-N'-1,3-thiazol-2-ylurea · in 2 records
- N64 · N-(5-methyl-1,2-oxazol-3-yl)-N'-[3-(4-phenylpiperazin-1-yl)propyl]urea · in 2 records
- N6D · N-[3-(methoxymethyl)phenyl]-N'-(5-methyl-1,2-oxazol-3-yl)urea · in 2 records
- N6V · N-{1-[2-(diethylamino)ethyl]-1H-indol-5-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea · in 2 records
- 04E · iodoacetic acid · in 1 record
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 1 record
- N5D · N-cyclopropyl-2-(4-{[(5-methyl-1,2-oxazol-3-yl) carbamoyl]amino}-1H-pyrazol-1-yl)acetamide · in 1 record
- N67 · N-methyl-5-({[(5-methyl-1,2-oxazol-3-yl) carbamoyl]amino}methyl)thiophene-2-sulfonamide · in 1 record
- N6J · N-{1-[(imidazo[1,2-a]pyridin-2-yl)methyl]-1H-pyrazol-4-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea · in 1 record
- N71 · N-(5-methyl-1,2-oxazol-3-yl)-N'-[2-(phenylsulfonyl) ethyl]urea · in 1 record
- N74 · N-(1-benzyl-1H-pyrazol-4-yl)-N'-(5-methyl-1,2-oxazol-3-yl)urea · in 1 record
Elsewhere
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