Research workbench
Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with ran
Analyse Crystal structure of transportin-SR2, a karyopherin involved in human disease… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OL0
- Type
- protein
- Length
- 1,074 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding nuclear protein ran; Transportin-3
- UniProt
- P62826, Q9Y5L0
- Ligands
- GTP, MG
- Pockets
- 13 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding nuclear protein ran | protein | 172 | 26% helix, 28% strand | P62826 |
| B | Transportin-3 | protein | 902 | 73% helix, 0% strand | Q9Y5L0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1072 | 0.78 | 0.80 | 68 | empty |
| 2 | 890 | 0.75 | 0.79 | 83 | MG, GTP |
| 3 | 495 | 0.74 | 0.83 | 48 | empty |
| 4 | 138 | 0.63 | 0.86 | 30 | empty |
| 5 | 204 | 0.53 | 0.78 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 2179 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 4OL0 · Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y5L0 · AlphaFold monomer V2.0 prediction for transportin-3 (Q9Y5L0) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62826
- Every structure of UniProt Q9Y5L0
- Elsewhere: RCSB PDB 4OL0 · PDBe 4OL0 · UniProt P62826 · UniProt Q9Y5L0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.